冠心病血瘀证患者外周血细胞微粒结合体水平的研究  

Microparticles aggregates of peripheral blood in the unstable angina pectoris patients with blood stasis pattern

作　　者：贾秋蕾 孟昊[1] 胡元会[1] 褚瑜光[1] 石晶晶[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053 [2]北京中医药大学

出　　处：《北京中医药大学学报》2017年第1期59-64,共6页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：目的探讨冠心病不稳定心绞痛(UA)患者外周血血小板微粒(PMP)与白细胞微粒(LMP)、内皮细胞微粒(EMP)、红细胞微粒(RMP)间形成的结合体与冠心病严重程度的关系。方法将冠心病患者分为血瘀证组和非血瘀证组。利用显微成像流式细胞术观察冠心病UA患者PMP与LMP、EMP、RMP间形成的结合体水平并观察其形态,检测结合体在冠心病UA血瘀证及非血瘀证患者外周血细胞中的差异。结果冠心病UA血瘀证患者PMP、LMP、EMP、RMP、PMP-EMP结合体、PMP-RMP结合体表达水平高于非血瘀证患者(P<0.05),且与血瘀证呈正相关(P<0.01)。结论 PMP、LMP、EMP、RMP、PMP-EMP结合体、PMP-RMP结合体参与了冠心病UA血瘀证的形成。Objective To observe the relationship between aggregates,including platelet-derived microparticle（PMP）-leukocyte microparticle（LMP）,PMP-endothelial microparticle（EMP）,and PMP-red cell microparticle（RMP）,and severity of coronary heart disease（CHD）.Methods All CHD patients were divided into blood stasis pattern group and non blood stasis pattern group.The aggregates of PMPLMP,PMP-EMP,and PMP-RMP in patients with unstable angina pectoris（UA） were detected and their morphology was observed by using imaging flow cytometry.Then the aggregates level of patients of the two groups were analyzed.Results The expression of PMP,LMP,EMP,RMP,PMP-EMP and PMP-RMP in patients with blood stasis pattern were higher than those of patients without blood stasis pattern（P〈0.05）,which were positively correlated with blood stasis syndrome（P〈0.01）.Conclusion It showed that PMP,LMP,EMP,RMP,PMP-EMP and PMP-RMP played an important role in the formation of UA with blood stasis pattern.

关 键 词：冠心病 血瘀证 微粒 结合体 

分 类 号：R259.414[医药卫生—中西医结合]