罗库溴铵不同给药方法对依托咪酯引发肌阵挛的影响  

EFFECTS OF ROCURONIUM PRE-ADMINISTRATION ON ETOMIDATE-INDUCED MYOCLONUS

作　　者：刘慧芳[1] 温再和[1] 于建设[1] LIU Hui-fang WEN Zai-he YU Jian-she(Affiliated Hospital,Inner Mongolia Medical University,Hohhot 010050 China)

机构地区：[1]内蒙古医科大学附属医院麻醉科,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2016年第4期325-327,331,共4页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金(2015MS0803)

摘　　要：目的：研究预先注射罗库溴铵对全麻诱导期依托咪酯引发肌阵挛的影响。方法：选择100例男性病人,ASAⅠ或Ⅱ级,年龄20～60岁,全身麻醉下行择期手术。随机分为2组罗库溴铵预给药组（R组）和对照组（S组）,每组50例。两组病人先给予芬太尼3μg/kg,面罩吸氧2 min后,R组给予罗库溴铵0.3 mg/kg,顺序注射依托咪酯0.3 mg/kg、罗库溴胺0.3 mg/kg;B组给与等容积生理盐水,依托咪酯0.3 mg/kg、罗库溴胺0.6 mg/kg,依托咪酯的速度推注速度为1 mg/s。记录两组病人麻醉前（T1）、给予依托咪酯后（T2）、给予依托咪酯1 min后（T3）、插管后（T4）HR、SBP、SPO2变化及肌震颤发生情况。结果：两组病人一般情况差异无统计学意义（P〉0.05）。麻醉诱导过程中S组在T2时HR明显高T1（P〈0.05）,且在T2时间点时S组HR较R组心率增加（P〈0.05）,SBP及SPO2无明显变化,无统计学意义（P〉0.05）。与S组比较,R组病人没有发生肌阵挛、肌阵发生率显著降低（P〈0.01）。结论：罗库溴铵预给药对缓解依托咪酯引发的肌阵挛切实可行。Objective： To observe the effects of pre-injection of Rocuronium on etomidate-induced myoclonus in induction of anesthesia. Methods： 100 consenting ASA Ⅰ-Ⅱmale patients,aged from 20 ～ 60 years were selected for undergoing elective surgery under general anesthesia. They were randomly divided into rocuronium group（ group R,n = 50） and saline group（ group S,n = 50）. All Patients were given 3 ug / kg fentanyl and 2 min oxygen mask. Group R patients were received 0. 1 mg / kg rocuronium,sequentially injected 0. 3 mg / kg etomidate,0. 5 mg / kg rocuronium; Group S were given the same volume of saline,0. 3 mg / kg etomidate,0. 6 mg / kg rocuronium. Each group were infused etomidate speed in 1 mg / s. The occurrence and severity of myoclonus were recorded,SBP、HP、SPO2were measured during the study period（ before anesthesia T1、gave etomidate T2、1 min after gave etomidate T3、after intubation）. Results： There were no significant differences in general（ P〈0. 05） between two groups. The HR were higher in group R than group S at T2（ P〈0. 05）,and compared with group R,the HR were higher in group S at T2（ P〈0. 05）,SBP and SPO2 had no significant changes in the two group（ P〈0. 05）. The incidence of myoclonus was significantly lower in group R（ 0%） than that（ 80%） in group S（ P〈0. 01）. Conclusion： It＇s feasible that Rocuronium pre-administration can relieve Etomidate-induced myoclonus.

关 键 词：罗库溴铵 预给药 肌阵挛 依托咪酯 

分 类 号：R452[医药卫生—治疗学]