^(18)F-PET/CT显像在甲状腺癌失分化患者定期复查中临床意义研究  

Study on Clinical Significance of ^(18)F-PET/CT Imaging in Periodic Reviews in Patients with Thyroid Carcinoma Differentiation

作　　者：别冬云[1] 王燕妮[1] 

机构地区：[1]湖北省荆州市第一人民医院核医学科,湖北荆州434000

出　　处：《中国CT和MRI杂志》2017年第3期36-38,共3页Chinese Journal of CT and MRI

基　　金：国家自然科学基金(81172742;81473053)

摘　　要：目的探讨18F-PET/CT显像在甲状腺癌失分化患者定期复查中的应用价值。方法收集我院2012年1月至2016年6月收治的行18F-FDG PET/CT检查的分化型甲状腺癌患者45例作为研究对象展开回顾性分析,以手术/随访结果为基准,计算18F-FDG PET/CT的敏感性与阳性预测值。结果 45例患者中,18F-FDG PET/CT检查示42例患者为阳性显像,敏感性为93.3%(42/45)。45例患者共发现105个颈部转移淋巴结、9例肺转移、6枚纵隔淋巴结,术后病理证实111个为肿瘤复发或转移、9例为炎性病灶,阳性预测值为92.5%(111/120)。结论 18F-FDG PET/CT显像在术后大剂量131I治疗后Tg升高而131I-全身扫描结果显示为阴性的失分化甲状腺癌患者中的应用,可通过对肿瘤代谢状态的观察有效避免漏诊,以定期复查方式尽早发现患者复发或转移病灶,并为后续治疗提供指导。Objective To explore the application value of ^18F-PET/CT imaging in periodic reviews in patients with thyroid carcinoma differentiation. Methods 45 patients with thyroid carcinoma differentiation who underwent ^18F-FDG PET/CT examination in our hospital from January 2012 to June 2016 were enrolled in the study to carry out retrospective analysis, operation/follow up results were called a baseline, sensitivity and positive predictive value of ^18F-FDG PET/CT were calculated. Results ^18F-FDG PET/ CT examination found that 42 patients were positive imaging in 45 patients, sensibilitT was 93.3% （42/45）. 105 cases of cervical lymph node metastasis, 9 cases of puhnonary lymph nodes, 6 cases ofmediastinal lymph nodes were found in 45 patients, postoperative pathologic confirmed that 111 cases were tumor recurrence or metastasis, 9 cases were inflammatory disease, positive predictive value was 92.5%（111/120）. Conclusion ^18F- FDG PET/CT imaging after postoperative large dose 131I treatment, Tg is increased. 131I-body scan results show that negative patients with thyroid carcinoma differentiation can aviod missed diagnosis effectively by the observation of tumor metabolism, periodic reviews can find out recurrence or metastatic lesions as soon as possible, and provide guidance for follow-up treatment, has significant clinical application value.

关 键 词：甲状腺癌 失分化 ^18F-PET/CT显像 复发与转移 摄取 

分 类 号：R445.3[医药卫生—影像医学与核医学] R736.1[医药卫生—诊断学]