中西药结合治疗面部寻常型痤疮的临床观察  

Treatment of Facial Acne Vulgaris by Chinese Medicine Combined Western Medicine

作　　者：常晓丹[1] 戴珊[1] 叶珍珍[1] 宋清华[1] 

机构地区：[1]北京大学第三医院皮肤科,北京100191

出　　处：《中国中西医结合杂志》2017年第2期160-164,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的对比观察夫西地酸、龙珠软膏及联合盐酸米诺环素治疗面部寻常型痤疮的疗效。方法186例患者分为夫西组(103例)与龙珠组(83例),根据痤疮轻重又分为单用及联合用药治疗。夫西组轻度患者单用夫西地酸(39例),重度患者同时联合口服盐酸米诺环素(64例);龙珠组轻度患者单用龙珠软膏(27例),重度患者同时联合口服盐酸米诺环素(56例)。观察4周,每周复诊1次,并对皮损进行全球痤疮综合分级系统(GAGS)评分,用VISIA皮肤分析仪记录皮肤斑点、红色区等数据进行统计分析。结果夫西组、龙珠组治疗后GAGS评分与治疗前比较,差异均有统计学意义(P<0.05);夫西组、龙珠组单用患者总有效率分别为64.1%(25/39)和66.7%(18/27),联合用药患者总有效率分别为70.3%(45/64)和62.5%(35/56),两组总有效率比较,差异均无统计学意义(χ~2=0.09,χ~2=0.04,P>0.05)。VISIA皮肤分析仪结果显示,与治疗前比较,夫西组、龙珠组的单用患者治疗后红色区差异均有统计学意义(P<0.05);联合用药患者治疗后紫外线、红色区、紫质差异均有统计学意义(P<0.05)。结论夫西地酸、龙珠软膏可有效控制痤疮炎症,且龙珠软膏起效快;联合盐酸米诺环素后,夫西地酸可显著减少油脂分泌,龙珠软膏防御紫外线作用明显。Objective To comparatively observe clinical efficacies of Fusidic Acid Cream（ FAC）,Longzhu Ointment（ LO）,and their combination of minocycline hydrochloride for treating facial acne vulgaris.Methods Totally 186 patients with acne vulgaris were randomly assigned to the FAC group（ 103cases） and the LO group（ 83 cases）.Each group was further divided into two subgroups according to the severity of acne： single treatment group and united treatment group.Patients with mild acne vulgaris in the FAC group received FAC alone（ 3 9 cases）,and those with severe acne vulgaris in the FAC group received FAC and minocycline hydrochloride（ 64 cases）.Patients with mild acne vulgaris in the LO group received LO alone（ 2 7 cases）,and those with severe acne vulgaris in the LO group received LO and minocycline hydrochloride.The therapeutic course for all was 4 weeks,with one return visit once per week.Grading of skin lesions was assessed by global acne grading system（ GAGS）.Clinical improvement was evaluated.Skin spots,red areas,and other data were statistically analyzed by VISIA skin analyzer.Results GAGS score was statistically different between before and after treatment in the FAC group and the LO group（P〈0.05）.The total effective rate was 64.1 %（ 25 /39） in single treatment group of the FAC group and 66.7 %（ 18 /27） in single treatment group of the LO group,but with no statistical difference between the two groups（χ-2= 0.09,P〈0.05）.The total effective rate was 70.3 %（ 45/64） in united treatment group of the FAC group and 62.5 %（ 35 /56） in united treatment group of the LO group,but with no statistical difference between the two groups（χ-2= 0.04,P〉0.05）.Results of VISIA showed,compared with before treatment,statistical difference existed in red area of single treatment group of the FAC group and the LO group（P〈0.05）.Statistical difference existed in ultraviolet rays,red area,sclererythrin ofunited treatment group of the FAC group and the LO group（P〈0.05

关 键 词：寻常型痤疮 夫西地酸乳膏 龙珠软膏 VISIA皮肤分析仪 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]