糖化血红蛋白及血脂在糖尿病合并冠心病中的检测意义  

Detection significance of glycosylated hemoglobin and serum lipids in patients with diabetes mellitus complicated with coronary heart disease

作　　者：肖春洁[1] 

机构地区：[1]沈阳军区总医院附属北方医院检验科,辽宁沈阳110031

出　　处：《中国当代医药》2017年第3期129-131,共3页China Modern Medicine

摘　　要：目的探讨糖化血红蛋白(Hb A1c)及血脂在糖尿病合并冠心病中的检测意义。方法选择2015年6月~2016年6月就诊于本院内分泌科的2型糖尿病患者共185例,其中98例2型糖尿病合并冠心病患者作为合并症组,87例单纯性2型糖尿病患者作为糖尿病组,再选取同期于本院进行体检的60例健康人作为对照组。然后对三组患者TC、TG、LDL-C、HDL-C、APOA-I、APOB、Hb A1c的水平进行统计分析。从185例2型糖尿病患者中随机选出80例,将入院时空腹血糖水平≥11.10 mmol/L作为A组,7.0 mmol/L≤空腹血糖水平<11.10 mmol/L作为B组,然后分析血糖与血脂之间的关系。结果糖尿病组与合并症组TC、TG、LDL-C、APOB及Hb A1c的检测水平明显高于对照组(P<0.05);HDL-C和APOA-Ⅰ的检测水平明显低于对照组(P<0.05);合并症组TG、HDL-C及Hb A1c的检测水平与糖尿病组比较,差异有统计学意义(P<0.05)。A组患者TG含量明显高于B组[(2.76±1.32)mmol/L vs.(1.93±1.06)mmol/L](P<0.05),APOB水平较B组高[(1.34±0.19)g/L vs.(1.18±0.23)g/L],差异有统计学意义(P<0.05)。结论TG、HDL-C及Hb A1c是2型糖尿病患者并发冠心病的预测指标;血糖水平越高的患者越易出现脂类代谢异常,越易造成血管内皮功能损伤,所以临床上严格控制2型糖尿病患者的血糖、血脂水平,能够对延缓、预防冠心病的发生起到重要作用。Objective To investigate significance of glycosylated hemoglobin and serum lipids detection in patients with diabetes mellitus complicated with coronary heart disease.Methods A total of 185 patients with type 2 diabetes mellitus in Department of Endocrinology of the hospital were selected from June 2015 to June 2016.Among them,98 patients with type 2 diabetes mellitus complicated with coronary heart disease were selected as complication group and 87 patients with simple type 2 diabetes mellitus as diabetes group,and then 60 healthy people for physical examination at the same period in the hospital were selected as control group.The levels of TC,TG,LDL-C,HDL-C,APOA-I,APOB,Hb A1 c were analyzed statistically.80 patients were randomly selected from 185 patients with type 2 diabetes mellitus,the fasting blood glucose level≥11.10 mmol/L was taken as group A,7.0 mmol/L≤fasting blood glucose level 11.10 mmol/L as group B,relationship between blood glucose and blood lipid was analyzed.Results The level of TC,TG,LDL-C,APOB and Hb A1 c in the diabetic group and the complication group was significantly higher than that in the control group;the levels of HDL-C and APOA- Ⅰ was significantly lower than that in the control group;the levels of TG,HDL-C and Hb A1 c in the complication group was significantly higher than that in the diabetic group,there was significant difference between two groups（P〈0.05）.The levels of TG in group A was significantly higher than that in group B [（2.76±1.32）mmol/L vs.（1.93±1.06）mmol/L]（P〈0.05）.APOB was significantly higher than that in group B [（1.34±0.19）g/L vs.（1.18±0.23）g/L],there was significant difference（P〈0.05）.Conclusion TG,HDL-C and Hb A1 c are the predictors of the development of type 2 diabetes mellitus patients with coronary heart disease.The patients with higher blood glucose levels are more prone to abnormal lipid metabolism,which may lead to vascular endothelial dysfunction.Therefore,strict control of type 2 diabetic patients mellitus with

关 键 词：2型糖尿病 冠心病 糖化血红蛋白 血脂 载脂蛋白 

分 类 号：R587.2[医药卫生—内分泌]