婴儿期的年龄别体重与幼儿期乙肝疫苗应答的关联  

Immune response to hepatitis B vaccine in infant associated with infant weight-for-age

作　　者：李媛媛[1] 蔡爱杰[1] 叶.叶克吉尔格力 戴江红[1] 

机构地区：[1]新疆医科大学公共卫生学院流行病与卫生统计学教研室,新疆乌鲁木齐830011

出　　处：《中华疾病控制杂志》2017年第1期40-43,47,共5页Chinese Journal of Disease Control & Prevention

基　　金：新疆维吾尔自治区自然科学基金-医学联合基金(2014211C001);新疆维吾尔自治区研究生科研创新项目(XJGRI2015079)

摘　　要：目的探讨婴儿期的年龄别体重与幼儿期儿童乙肝疫苗应答是否有关联。方法 2013年9月~2015年6月在新疆某三甲医院纳入检测乙肝两对半并完成0~1~6全程接种的儿童,并调查回顾其疫苗接种信息以及0~12月龄身高体重、父母一般情况、母亲孕期、儿童出生情况等。使用年龄别体重及其Z评分(weight for age Z score,WAZ)、年龄别体重偏离情况作为评价体格生长的指标,分析与乙肝疫苗应答的关联。结果 965名儿童纳入研究,男孩490人,女孩475人;平均年龄(1.34±0.56)岁,乙肝抗体阴性儿童占15.23%(147/965),抗体阴性组与阳性组父母一般情况、母亲孕期、儿童出生情况比较,差异均无统计学意义(均有P>0.05)。两组儿童1、3、6、9月龄别体重差异均有统计学意义(均有P<0.05),阴性组高于阳性组。两组儿童1、3、6年龄WAZ、体重偏离情况差异均有统计学意义(均有P<0.05);1月龄(OR=3.409,95%CI:2.199~5.286)、3月龄(OR=5.339,95%CI:3.128~9.113)、6月龄(OR=5.106,95%CI:2.910~8.958)超重者相对正常者的乙肝疫苗不应答率较高;1月龄(OR=3.554,95%CI:2.249~5.616)、3月龄(OR=5.785,95%CI:3.271~10.232)、6月龄(OR=4.486,95%CI:2.642~7.619)体重右偏离者相对正常者的乙肝疫苗不应答率较高。结论接种期(0~6月龄)体重对乙肝疫苗应答有影响,体格生长过快影响乙肝疫苗应答。Objective To investigate the association between infant immune response to hepatitis B vaccine and infant weight-for-age. Methods All infants with a complete HBV vaccination from the top three hospitals in Xinjiang province were detected for hepatitis B infection on the first time they came to the hospital from September 2013 to June 2015. A self-designed questionnaire was used to collect data on vaccination details,0-12 months height and weight information,general situation of parents,mother information during pregnancy,information of birth,and other information. Weight-for-age Z score（ WAZ） and weight deviation were used for the growth and physiology index assessment to analyze its association with immune response to hepatitis B vaccine. Results 490 boys and 475 girls of total 965 children with a mean age of（ 1. 34 ± 0. 56） were included in the study,among which HBV antibody-negative children accounted for 15. 23%（ 147 /965）. There was no significant difference in the general situation of parents,mother information during pregnancy,information of birth between group（-） and（ ＋）（ all P〉0. 05）. Compared group（-） and（ ＋） by 1,3,6 month weight,the difference was statistically significant（ all P〈0. 05）. Infants in group（-） were heavier than those in group（ ＋）. Compared group（-） and（ ＋） by 1,3,6 month WAZ,weight deviation,the difference was statistically significant（ all P〈0. 05）. The OR of overweight relative to normal in 1 month was 3. 409,95% CI： 2. 199-5. 286,3 month was 5. 339,95%CI： 3. 128-9. 113 and 6 month was 5. 106,95% CI： 2. 910-8. 958,overweight group had higher non-response rate compared with normal group. The OR of right-deviation to normal in 1 month was 3. 554,95% CI： 2. 249-5. 616,3 month was 5. 785,95% CI： 3. 271-10. 232 and 6 month was 4. 486,95% CI： 2. 642-7. 619,overweight group had higher non-response rate compared with normal group. Conclusions The weight of 0-6 months（ inoculation period） will affect the leve

关 键 词：婴儿 体重 肝炎疫苗 乙型 

分 类 号：R186.7[医药卫生—流行病学]