支气管哮喘合并肺结核患者脑源性神经营养因子和神经激肽A表达对预后的影响分析  

Effects of BDNF and NKA expression on the prognosis of patients with bronchial asthma complicated with tuberculosis

作　　者：刘畅[1] 周向东[1] 李华[1] 韩忠[1] 王杰[1] LIU Chang ZHOU Xiang-dong LI Hua HAN Zhong WANG Jie(Hainan Medical College Affiliated Hospital, Haikou, Hainan 570102, China)

机构地区：[1]海南医学院附属医院呼吸内科,海南海口570102

出　　处：《中华医院感染学杂志》2017年第4期785-787,791,共4页Chinese Journal of Nosocomiology

基　　金：海南省科技厅基金资助项目(琼卫科教函<2009>47309066)

摘　　要：目的探究支气管哮喘合并肺结核患者脑源性神经营养因子(BDNF)和神经激肽A(NKA)表达对预后的影响,以便于更好地监测患者病情进展,改善患者预后,提高患者生活质量。方法随机选取2014年1月-2015年12月医院收治55例支气管哮喘合并肺结核患者为观察组对象,另选取30名在医院体检的健康成人为对照组,观察并记录两组受试者治疗前后BDNF、NKA、第一秒用力呼吸量(FEV1)和呼气峰值(PEF)变化情况,分析比较。结果哮喘急性期患者BDNF水平显著高于哮喘缓解期患者和对照组,治疗后,缓解期和急性期支气管哮喘患者BDNF均下降,与治疗前比较差异有统计学意义(P<0.05);支气管哮喘缓解期患者NKA显著高于对照组,而哮喘急性期患者显著高于缓解期患者,两组比较差异有统计学意义(P<0.05),治疗后,均有明显降低,较治疗前差异有统计学意义(P<0.05);治疗后,两组患者FEV1和PEF等肺功能指标明显改善,较治疗前差异有统计学意义(P<0.05)。结论支气管哮喘患者体内NKA和BDNF含量较正常人显著升高,有利于疾病早期诊断和监测,便于控制病情发展,预后较好。OBJECTIVE To explore the effect of brain derived neuroptrophic factor（BDNF）and neurokinin A（NKA）expression on the prognosis of patients with bronchial asthma complicated with tuberculosis,so as to better monitor the progress of the patients＇ condition,improve their prognosis,and improve their quality of life.METHODS A total of 55 case of bronchial asthma with tuberculosis patients from Jan.2014 to Dec.2015 in our hospital were randomly selected as observation group,and another 30 healthy adults in the hospital were selected as control group.The changes of BDNF,NKA,FEV1 and PEF of the two groups before and after treatment were observed and recorded,and the results were analyzed and compared.RESULTS BDNF level in patients with acute asthma was significantly higher than that in asthmatic patients in remission stage and control group.After treatment,BDNF levels of patients with remission and acute bronchial asthma decreased,and had statistically significant differences compared with those before treatment（P〈0.05）.NKA in patients with bronchial asthma in stable stage was significantly higher than that of control group,whereas in patients with acute asthma was significantly higher than patients in stable stage,and the difference of the two groups was statistically significant（P〈0.05）.The NKA levels after treatment were significantly lower than those before treatment,and there were statistically significant differences（P〈0.05）.After treatment,the pulmonary function indexes of FEV1 and PEF of the two groups were significantly improved,and there were statistically significant differences（P〈0.05）than those before treatment.CONCLUSIONThe levels of NKA and BDNF in bronchial asthma patients are significantly higher than those in normal persons,The levels of NKA and BDNF in bronchial asthma patients were significantly higher than those in normal subjects,which are helpful to the early diagnosis,monitoring of the disease and the better control of the disease with good prognosis.

关 键 词：支气管哮喘 肺结核 脑源性神经营养因子 神经激肽A 预后 

分 类 号：R521[医药卫生—内科学]