人乳头状瘤病毒感染对宫颈上皮内瘤变及宫颈癌患者组蛋白去乙酰化酶1及基质金属蛋白酶表达的影响研究  

Influence of human papillomaviral infection on the expressions of histone deacetylase 1 and matrix metalloproteinase of patients with cervical intraepithelial neoplasia and cervical cancer

作　　者：卢建军[1] 宋建东[1] 杨鹏霞[1] 蒋红[1] 刘娟娟[1] LU Jian-jun SONG Jian-dong YANG Peng-xia JIANG Hong LIU Juan-juan(The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010059, China)

机构地区：[1]内蒙古医科大学附属医院妇产科,内蒙古呼和浩特010059

出　　处：《中华医院感染学杂志》2017年第4期884-887,共4页Chinese Journal of Nosocomiology

基　　金：内蒙古自治区自然科学基金资助项目(2014MS0849)

摘　　要：目的研究人乳头状瘤病毒(HPV)感染对宫颈上皮内瘤变及宫颈癌患者组蛋白去乙酰化酶1(HDAC1)及基质金属蛋白酶(MMPs)表达的影响,为宫颈上皮内瘤变及宫颈癌的诊治提供参考依据。方法选取2014年4月-2016年3月医院收治39例宫颈癌患者为A组,39例宫颈上皮内瘤变患者为B组,39名健康妇女为C组,检测与比较3组研究者组织HDAC1及MMP指标表达情况,并比较A组与B组中不同HPV感染者的上述指标表达水平。结果 A组患者组织HDAC1及MMP-2、MMP-3、MMP-7、MMP-9阳性表达率为71.79%及66.67%、64.10%、64.10%、66.67%,均高于B组患者38.46%及43.59%、38.46%、30.77%、35.90%,C组5.13%及7.69%、2.56%、2.56%、5.13%,B组患者阳性表达率则高于C组,A组和B组中HPV感染者阳性表达率高于HPV阴性者,且B组中高度病变者阳性表达率高于低度病变者,差异有统计学意义(P<0.05)。结论HPV感染对宫颈上皮内瘤变及宫颈癌患者组织的HDAC1及MMP指标表达影响较大,因此应重视对上述指标的监测与控制。OBJECTIVE To study the influence of human papillomaviral（HPV）infection on the expressions of histone deacetylase 1（HDAC1）and matrix metalloproteinase（MMPs）of patients with cervical intraepithelial neoplasia and cervical cancer,so as to provide guidance for the diagnose and treatment of cervical intraepithelial neoplasia and cervical cancer.METHODS A total of 39 patients with cervical cancer in our hospital from Apr.2014 to Mar.2016 were selected as group A,39 patients with cervical intraepithelial neoplasia were selected as group B,39 healthy women were selected as group C,then the tissue HDAC1 and MMP indexes of the three groups were detected and compared,and expression levels of those indexes of group A and group B were compared too.RESULTS The positive rates of tissue HDAC1 and MMP-2,MMP-3,MMP-7,and MMP-9of group A were 71.79%,66.67%,64.10%,64.10% and 66.67%,respectively,which were all higher than 38.46%,43.59%,38.46%,30.77%,35.90% of group B and 5.13%,7.69%,2.56%,2.56%,5.13% of group C,the positive rates of group B were all higher than those of group C,the positive rates of group A and group B with HPV infection were all higher than those of patients without HPV infection,and the positive rates of group B with high-grade lesion were all higher than those of patients with low-grade lesion,and the differences were all statistically significant（all P〈0.05）.CONCLUSIONThe influence of human papillomaviral infection on the expressions of histone deacetylase1 and matrix metalloproteinase of patients with cervical intraepithelial neoplasia and cervical cancer are great,so it should pay attention to the monitoring and control of these indicators.

关 键 词：人乳头状瘤病毒感染 宫颈上皮内瘤变 宫颈癌 组蛋白去乙酰化酶1 基质金属蛋白酶 

分 类 号：R379[医药卫生—病原生物学]