无症状高尿酸血症患者综合干预的疗效观察  

Clinical effect of comprehensive intervention on 182 cases of asymptomatic hyperuricemia

作　　者：邓卫[1] 谢辉[1] 张海红[1] 谭晓军[1] 

机构地区：[1]开平市中心医院肾内科,529300

出　　处：《实用医学杂志》2017年第3期443-446,共4页The Journal of Practical Medicine

基　　金：广东省科技计划(编号:2013B022000031)

摘　　要：目的:探讨综合干预无症状高尿酸血症的治疗效果,探究简单易行有效的综合干预模式。方法:本研究为随机对照试验设计。将在本院体检中符合纳入标准的182例无症状高尿酸血症患者随机分为干预组和对照组,干预组在强化生活方式的基础上予以碳酸氢钠片口服治疗,对照组予以低嘌呤饮食干预。随访1年。分析干预组干预前后及干预后两组观察指标的变化。结果:1年后干预组患者BMI、血尿酸、血糖、收缩压、舒张压、甘油三酯水平及患肥胖、高血糖、高血压、高甘油三酯血症的比例均低于对照组,差异均有统计学意义(均P<0.05)。干预组干预后BMI、血尿酸、血糖、舒张压、甘油三酯水平及患肥胖、高血糖、高血压、高甘油三酯血症的比例均低于干预前,差异有统计学意义(均P<0.05)。结论:综合干预无症状高尿酸血症患者效果较好,且比单纯低嘌呤饮食干预更能降低血尿酸,减少肥胖、高血糖、高甘油三酯血症、高血压并发症的发生。Objective To investigate the effect of comprehensive intervention on asymptomatic hyperurieemia. Methods in this random controlled study, all patients diagnosed with asymptomatic hyperuricemia on health examination according to the diagnostic standards were randomly divided into intervention group and control group. Comprehensive intervention included healthy lifestyle guidance and administration of sodium bicarbonate in the intervention group. Low purine diet was used in the control group. The follow-up period for all the patients was one year. The changes of various indexes in both groups before and after intervention were observed and compared. Results Compared with the control group, the patients in the intervention group presented significantly lower levels of BMI, serum uric acid, blood sugar, SBP, DBP, triglyceride and less frequent occurrence of obesity, hyperglycemi, hypertension, hipertrigliceridemia （P 〈 0.05）. After intervention, the patients in the intervention group also exhibited significantly lower the levels of BMI, serum uric acid, blood sugar, SBP, DBP, triglyeeride and significantly lower incidences of obesity, hyperglycemia, hypertension, hypercholesteremia and hipertrigliceridemia. Conclusion Comprehensive intervention into asymptomatic hypemricemia can reduce the incidence of complications such as central obesity, hyperglycemia, hyperlipidemia and hypertension.

关 键 词：无症状高尿酸血症 碳酸氢钠 干预 并发症 

分 类 号：R589.7[医药卫生—内分泌]