运动强度和时间对左右心室影响的比较研究  

A Comparative Study on Effects of Exercise Intensity and Duration on Left and Right Ventricular

作　　者：饶志坚[1,2] 常芸[1] 王世强[3] Rao Zhijian Chang Yun Wang Shiqiang(China Institute of Sports Science, Beijing 100061, China Shanghai University of Sport, Shanghai 200438, China College of Physical Education, Hunan University of Technology, Zhuzhou 412000, China)

机构地区：[1]国家体育总局体育科学研究所,北京100061 [2]上海体育学院运动科学学院,上海200438 [3]湖南工业大学体育学院,株洲412000

出　　处：《中国运动医学杂志》2017年第2期111-121,105,共12页Chinese Journal of Sports Medicine

基　　金：国家体育总局体育科学研究所基本科研业务经费(16-21)

摘　　要：目的:研究运动强度和时间对左右心室结构、功能和纤维化的影响及它们之间的异同,并初步探讨涉及的可能机理。方法:48只雄性SD大鼠,随机分为对照(Sed)组、中强度运动(ME)组和大强度运动(IE)组,每组又分为8周组和16周组,共6组,每组8只。对照组自由活动,中强度组和大强度组分别以速度15.2 m/min、坡度5°和速度28 m/min、坡度10°的条件每天运动1小时,每周运动5天。最后一次运动后,24小时内记录体重后使用心脏超声检测两心室的舒张末期内径和舒张末期室壁厚度及射血分数。采血后处死,迅速分离心脏。使用Elisa法检测大鼠血清cTnI浓度,天狼星红染色测定两心室的胶原容积分数。结果:在8周和16周时,中强度组和大强度运动组大鼠两心室舒张末期内径都大于对照组。仅16周时大强度组左心室舒张末期内径大于中强度组,其它中强度组和大强度组间左心室或右心室舒张末期内径无差异。随着运动强度增加和运动时间的推移,左心室及右心室舒张末期室壁厚度都有增加的趋势,但无统计学意义。大强度运动8周后,大鼠两心室的射血分数都有低于对照组和中强度组的趋势,但无统计学意义;而大强度运动16周后,两心室射血分数显著低于对照组和中强度组。大强度运动8周或16周后,血清cTnI显著高于对照组和中强度组,中强度组与对照组无差异。16周中强度组或大强度组两个心室的胶原容积分数大于8周时相应的组。8周或16周大强度运动组的右心室胶原容积分数显著大于相应的对照组,且16周时大强度组右心室胶原容积分数显著大于中强度组;而左心室相应的比较无差异。大鼠血清cTnI浓度与左心室和右心室收缩功能均负相关(r=-0.327,P=0.029和r=-0.582,P=0.000);大鼠血清cTnI浓度与左心室胶原容积分数不相关(P=0.276),但与右心室胶原容积分数中度正相关(r=0.597,P=0.000)。结论:1)16周�Objective To examine the effects of exercise intensity and duration on the structure,func-tion and fibrosis of the left and right ventricular,and to discuss the potential mechanism in these pro-cesses. Methods Forty-eight male Sprague-Dawley rats were randomly divided into a sedentary（Sed）group,a moderate exercise（ME）group and an intensive exercise（IE）group,each of 16. Rats in Sedgroup were not given any training,while those in ME group and IE group run on treadmill at thespeed of 15.2 m/min with the slope gradient of 5° and 28 m/min with the slope gradient of 10 degree1 hour per day,5 days per week. Eight and 16 weeks after the training,we recorded the body weightand measure end-diastolic diameter,end-diastolic wall thickness,and ejection fraction of both ventricu-lars using the ultrasonic testing. All rats were then sacrificed after blood sampling. Elisa was used tomeasure serum cTnI concentration,and sirius red staining was applied to evaluate collagen volume frac-tion of both ventriculars. Results Eight or sixteen weeks after the training,the average bi-ventricularend-diastolic diameter of ME and IE rats was bigger than Sed group. There were no differences inend-diastolic diameter of both ventricular between ME group and IE group after sixteen-week training,but the left ventricular end-diastolic diameter of IE group was greater than ME group. As exercise in-tensive increased and time accumulated,the end-diastolic wall thickness of both ventriculars increasedbut without statistical significance. At sixteen-week intervention,the bi-ventricular ejection fraction ofIE rats was significantly lower than Sed and ME groups,while there was a decreasing trend eightweeks earlier without significant differences. After 8 or 16 weeks of training,the serum cTnI was signifi-cantly higher in IE rats than Sed group or ME group,but there was no significant differences betweenME group and Sed group. After 16 weeks＇ exercises,the average bi-ventricular collagen volume frac-tion of ME or IE group was greater than th

关 键 词：运动心脏重塑 左心室 右心室 心肌纤维化 c TN I 运动强度 运动时间 

分 类 号：R87[医药卫生—运动医学]