PET／CT脑代谢显像对耳鸣病人的研究价值  

A PET / CT STUDY OF CEREBRAL METABOLIC MAPPING IN PATIENTS WITH TINNITUS

作　　者：林美福[1] 陈文新[1] 李瑞玉[2] 陈洪[2] 周硕[1] 陈彩龙[1] 陈国宝[1] 戴红峰[1] 

机构地区：[1]福建医科大学省立临床医学院核医学科,福建福州350001 [2]福建医科大学省立临床医学院耳鼻咽喉科

出　　处：《内蒙古医科大学学报》2016年第5期429-432,共4页Journal of Inner Mongolia Medical University

基　　金：福建省自然科学基金(2012J01319)

摘　　要：目的:通过对耳鸣病人相关脑区18F-FDG PET/CT代谢变化的研究,确定主观性耳鸣与神经中枢的对应关系。方法:采用SPM(Statistical parameters mapping)统计软件及感兴趣区(ROI)技术对34例耳鸣病人及40例健康对照组18F-FDG PET/CT脑显像进行分析。结果:34例耳鸣病人中,目测法共有52个脑区葡萄糖代谢增高;SPM分析主要位于颞上回(BA22)和颞中回(BA21),涉及的脑区还有上前扣带皮层(BA32),海马旁皮层(BA36),梭状回(BA37),缘上回(BA40)等共83个脑区,检出病灶多于目测法。结论:主观性耳鸣病人相关脑区的改变不仅局限于听中枢,与边缘系统及额叶联合区、主次级听觉皮层有一定关系;且与耳鸣侧别无关。Objective： To investigate the metabolic changes of 18SF- FDG PET/CT in related cerebral regions of tinnitus, and to confirm the correspondence between subjective tinnitus and nerve center. Methods：18SF-FDG PET/CT cerebral imaging were performed on 3d tinnitus patients and 40 controls, and the results were analyzed with SPM （Statistical parameters mapping）and region of interest （ROI）. Results：There were 52 increased metabolism brain areas were demonstrated by the visual method. SPM analysis demonstrated that the most consistently activated regions in tinnitus subjects were superior temporal gyrus（BA22） and middle temporal gyrus（ BA21 ）, For some patients, other specific foci, such as dorsal anterior cingulate cortex （ BA32 ）, parahippocampal cortex （ BA36 ）, fusiform gyrus （BA37）, supramarginal gyrus（BA40） were involved, and it showed more high activity regions than the visual method. Conclusion： The metabolic c subjective tinnitus were not only limited to the hanges of related cerebral regions in patients with auditory center, but also had a certain relationship with the junction of limbic system and the frontal lobe,the primary and secondary auditory cortex. The high metabolic regions were independent from tinnitus laterality.

关 键 词：耳鸣 统计参数图 葡萄糖代谢 PET/CT 

分 类 号：R764.3[医药卫生—耳鼻咽喉科]