ZO-1/ZONAB信号通路与细胞的增殖分化  

The ZO-1/ZONAB Signaling Pathways and Cell Proliferation and Differentiation

作　　者：贺李娴 谭钢[1] He Lixian Tan Gang(Department of Ophthalmology, The First Affiliated Hospital, University of South China, Hengyang 421001, China)

机构地区：[1]南华大学附属第一医院眼科,衡阳421001

出　　处：《中国细胞生物学学报》2017年第1期128-134,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81100648;81400372)资助的课题~~

摘　　要：闭合小带蛋白-1(zonula occludens-1,ZO-1)相关性核酸结合蛋白(ZO-1-associated nucleic acid binding protein,ZONAB)是一种Y-box转录抑制因子。ZONAB结合于ZO-1的SH3(Src homology 3)结构域,并与多种调控细胞周期的基因、蛋白质、酶、转录因子等相互作用,共同构成ZO-1/ZONAB信号通路。研究证实,ZO-1/ZONAB信号通路参与多种细胞的增殖与分化、基因表达及器官发生等过程的调控,主要涉及肾小管、视网膜、角膜、肺泡上皮、神经胶质细胞及肿瘤等组织细胞。ZO-1/ZONAB信号通路调控细胞增殖分化的具体机制尚未完全阐明,但已在细胞再生、干细胞医学及肿瘤学等领域显示出潜在而巨大的研究价值。该文主要针对ZO-1/ZONAB信号通路与细胞增殖分化的最新研究进行综述。ZONAB（zonula occludens-1-associated nucleic-acid-binding protein）, which is recruited to tight junction by binding to the SH3（Src homology 3） domain of ZO-1（zonula occludens-1）, is a Y-box transcription factor. The interaction between ZO-1 and ZONAB is regulated by various types of cyclin-related genes, proteins, enzymes or transcription factors, which forms the ZO-1/ZONAB signaling circuitry. Recent evidence showed that ZO-1 and ZONAB interact to modulate cell proliferation, differentiation, genetic expression and morphogenesis, which were studied in the tissue of renal tubule, retinal pigment epithelium, choroid, alveolar epithelium, neuroglia and tumor. Though the specific regulating mechanisms remain unclear, the ZO-1/ZONAB signaling has shown great value of research in the field of cell regeneration, stem cells and oncology. In this article, we reviewed current studies of the ZO-1/ZONAB signaling pathways relating to cell proliferation and differentiation.

关 键 词：ZO-1 ZONAB 紧密连接 细胞增殖 细胞分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]