CD4^＋T细胞亚群在类风湿关节炎中的研究  

Role of CD4^＋T Cell Subsets in Rheumatoid Arthritis

作　　者：殷文[1] 叶丛[1] 于飞[1] YIN Wen YE Cong YU Fei(Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Chin)

机构地区：[1]华中科技大学同济医学院附属同济医院风湿免疫科,武汉市430030

出　　处：《医学分子生物学杂志》2017年第1期44-48,共5页Journal of Medical Molecular Biology

基　　金：国家自然科学基金（No.81501415）

摘　　要：类风湿关节炎（rheumatoid arthritis，RA）是由多因素共同作用引起的自身免疫性疾病，至今发病机制仍未完全阐明，CD4^＋T细胞在RA的发生发展中发挥重要作用。早期发现Th1／Th2细胞后，新的CD4^＋T细胞亚群不断被发现，包括Th17细胞、Treg细胞、Th22细胞、Th9细胞和Tfh细胞。不同CD4^＋T细胞亚群在RA中表达异常，深入研究不同亚群CD4^＋T细胞在RA中的作用可为RA的发病机制提供线索。Rheumatoid arthritis （RA） is an autoimmune disease caused by multiple factors, and its pathogenesis has not yet been fully elucidated. CD4^＋T cells are demonstrated to play an important role in the development of RA. New CD4^＋T cell subsets, including Th17, Treg, Th22 cells, Th9 and Tfh cells, have been continuously found following the discovery of Th1/Th2 cells. They are abnormally expressed in RA. Further studying the role of CD4^＋T cell subsets in RA may provide clues for the pathogenesis of this condition.

关 键 词：类风湿关节炎 CD4^+T细胞亚群 

分 类 号：R593.22[医药卫生—内科学] R392.12[医药卫生—临床医学]