糖酵解与T细胞分化  

Glycolysis and T cell Differentiation

作　　者：黄海燕[1,2] 应颖[1,2] 彭勇[2] 陈勇[2] HUANG Haiyan YING Ying PENG Yong CHEN Yong(School of Medicine, Ningbo University, Ningbo, Zhefiang, 315211, China Department of Rheumatology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, 315010, China)

机构地区：[1]宁波大学医学院,浙江省宁波市315211 [2]宁波市第二医院风湿免疫科,浙江省宁波市315010

出　　处：《医学分子生物学杂志》2017年第1期49-54,共6页Journal of Medical Molecular Biology

基　　金：宁波市自然科学基金（No.2015A610206）

摘　　要：静止的T细胞和活化的T细胞之间的功能和表型特征的差异是由不同的代谢需求所支持的。T细胞活化以后。葡萄糖是其关键的代谢物以及腺苷三磷酸（adenosine triphosphate，ATP）产生的主要底物。有研究表明在缺乏葡萄糖，甚至有可替代的碳源如谷氨酰胺的情况下，T细胞的存活和增殖仍然会受损。活化后的T细胞体积会变大，通过磷脂酰肌醇-3激酶（phosphoinositide-3 kinase，PI3K）／丝氨酸．苏氨酸蛋白激酶（serine-threonine kinase，Akt）／雷帕霉素靶蛋白（target of rapamycin，mTOR）通路，从氧化磷酸化（oxidative phosphorylation，OXPHOS）过渡到糖酵解即Warburg效应，从而提高葡萄糖和氨基酸的利用率。文章重点讨论T细胞在分化过程中如何选择相应的代谢通路，并总结了糖酵解在T细胞分化过程中的相关机制，为今后寻找治疗免疫性相关疾病的新靶点提供了思路。Differences in functional and phenotypic characteristics of resting T cells and activated T cells are supported by different metabolic needs. Glucose is the key metabolite of T cells and the main substrate production by adenosine triphophate （ATP） after T cell activation. Studies have shown that in the absence of glucose, T cell survival and proliferation would be damaged even with alternative carbon sources such as glutamine. The volume of T cell will become larger after activated. Through phosphoinositide-3 kinase （PI3K） /Akt/mammalian target of rapamycin （roTOR） pathway, T cell will increase the utilization of glucose and amino acids from the oxidative phosphorylation （OXPHOS） to glycolysis which is called Warburg effect. Here, we discuss how T cell selects the appropriate metabolic pathways in the process of differentiation, and sum up the mechanisms of glycolysis in the differentiation of T cells, in an attempt to provide a clue for a new target of the treatment of immune-related diseases in the future.

关 键 词：糖酵解 T细胞分化 代谢 瓦伯格效应 

分 类 号：R343.8[医药卫生—基础医学]