合并心肌病的2型糖尿病大鼠与血浆GLP-1水平关系的研究  

Study on Cardiomyopathy in Type 2 Diabetic Rats and Plasma Levels of Glp-1 Relations

作　　者：江红[1] 段滨红[1] 杜馥曼[1] 向朝峰[1] 王丹[1] 王旭萍[1] 

机构地区：[1]黑龙江省医院内分泌科,150036

出　　处：《黑龙江医药》2017年第1期17-19,共3页Heilongjiang Medicine journal

基　　金：黑龙江省卫生厅课题2010-438

摘　　要：目的:观察合并心肌病的2型糖尿病大鼠与血浆GLP-1水平关系。方法:Wister大鼠随机分为对照组和糖尿病组,将成模糖尿病大鼠随机分为2组:心肌功能正常组与心肌病组,心肌病组给予阿霉素腹腔注射。采用超声仪检测大鼠左心室整体功能。应用酶免法(ELISA)方法测定各组大鼠空腹血清GLP-1水平。结果:糖尿病心肌功能正常组及糖尿病心肌病组的LVEF、LVFS、GLP-1水平明显下降(P<0.05)。与糖尿病心肌功能正常组比较,糖尿病心肌病组的LVEF、LVFS、GLP-1水平明显下降(P<0.05)。GLP-1水平与LVEF、LVFS呈正相关。结论:糖尿病心肌病大鼠LVEF、LVFS、GLP-1水平明显下降,GLP-1水平与LVEF、LVFS呈正相关。Objective：To explore the effect of Plasma levels of glp-1 on type 2 diabetic rats myocardial systolic and diastolic function. Methods：40 Wister rats were randomized to control group and diabetic diagroup. diabetic rats were randomized divided into 2groups： normal myocardial function and cardiomyopathy group. Cardiomyopathy group was given intraperitoneal injection of adriamycin. The ultrasonic instrument detecting left ventricular global function in rats. The EF 〈 42% as the diabetic cardiomyopathy in rats model building standards of success. ELISA method（ELISA） method is applied to determination of each group rats fasting serum levels of glp-1. Results：Diabetic myocardial function of normal and diabetic cardiomyopathy group LVEF, LVFS, glp-1 levels significantly decreased（P 〈 0.05）. Compared with diabetic myocardial functional groups, the LVEF of diabetic cardiomyopathy group, LVFS, glp-1levels significantly decreased（P 〈 0.05.）. Glp-1 levels and LVEF, LVFS were positively correlated. Conclusion：Diabetic cardiomyopathy rats LVEF, LVFS, glp-1 levels significantly decreased. Glp-1 levels and LVEF, LVFS were positively correlated.

关 键 词：糖尿病心肌病 胰高血糖素样肽-1 心室功能 

分 类 号：R587.2[医药卫生—内分泌]