真菌致敏哮喘患者的临床特征  

Analysis of clinic features of asthma patients with fungal sensitization

作　　者：李端芳[1,2] 蔡丽萍[3] 陈蕴光[3] 黄华兴[1] 邬勇坚[1] 阳隽[1] 赖荷[3] 

机构地区：[1]广州医科大学附属第二医院呼吸科,广东广州510260 [2]广州医科大学 [3]广州医科大学附属第二医院过敏反应科,广东广州510260

出　　处：《广东医学》2017年第2期214-216,共3页Guangdong Medical Journal

基　　金：广州医科大学博士启动项目(编号:2013C52)

摘　　要：目的分析哮喘患者真菌致敏的情况及其临床特征。方法哮喘患者行血清霉菌Ig E检测及变应原皮肤点刺试验,筛选出伴真菌致敏的哮喘患者,比较分析真菌致敏患者与不伴真菌致敏患者的临床特征。结果112例哮喘患者分为两组,26例患者血清霉菌Ig E和(或)霉菌皮肤点刺试验阳性,为真菌致敏组,余下86例为不伴真菌致敏组。真菌致敏组年龄明显低于不伴真菌致敏组(P=0.004);前者的重度哮喘患者比例高于后者(P=0.032);前者同时存在多种变应原致敏的比例明显高于后者(P<0.001);两组患者性别、合并变应性鼻炎和(或)皮炎比例、血清总Ig E、外周血嗜酸性粒细胞计数、第1秒用力呼气容积占预计值%(FEV1%)差异无统计学意义(P>0.05)。结论真菌为诱发哮喘的常见变应原之一,伴真菌致敏的哮喘患者平均年龄低、重度哮喘比例高,且常存在对多种变应原敏感的情况。Objective To analyze the clinic features of asthma patients with fungal sensitization.Methods Serum fungal special Ig E test and/or the skin prick test were carried out in enrolled patients.The clinical data was analyzed.The patients which were divided into fungal sensitization group（ n = 26,Group A） and fungal sensitization free group（ n = 86,Group B）.Results The age of Group A was significantly lower than that of Group B（ P = 0.004）.The severe asthma ratio patients in the Group A was significantly higher than that of Group B（ P = 0.032）.The ratio of accompanied multifarious allergens in Group A was also signfiicantly higher than that of Group B（ P〈 0.001）.There was no significant difference in the ratio of gender,amalgamate allergic rhinitis and/or allergic dermatitis,the serum total Ig E level,count of eosinophil and FEV1% between the two groups（ P 〈0.05）.Conclusion Fungus is a common allergen in asthma.Fungal sensitization asthma patients are younger and with higher morbidity in severe station.And they are often sensitive to various allergens.

关 键 词：真菌 变应原 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]