宁泌泰胶囊联合盐酸多西环素治疗溶脲脲原体阳性慢性前列腺炎的临床研究  

Ningmitai Capsules combined with doxycycline hydrochloride for Ureaplasma urealyticum-positive chronic prostatitis

作　　者：李莉华[1] 黄勋彬[1] 章慧平[1] 肖敦振[1] 柴劲松[1] 叶臻[1] 

机构地区：[1]华中科技大学同济医学院生殖医学中心,湖北武汉430030

出　　处：《中华男科学杂志》2017年第2期169-172,共4页National Journal of Andrology

摘　　要：目的:观察宁泌泰胶囊联合盐酸多西环素片对溶脲脲原体(Uu)引起的慢性前列腺炎的疗效。方法:采用随机对照研究方法,选取Uu阳性的慢性前列腺炎患者240例,随机分为中药组(35例)、西药组(78例)和联合组(127例),连续用药2周,观察临床疗效。中药组口服宁泌泰胶囊,4粒/次,3次/日;西药组口服盐酸多西环素片,100 mg/次,2次/日;联合组口服宁泌泰胶囊,4粒/次,3次/日,并联用盐酸多西环素片,100 mg/次,2次/日。结果:中药组、西药组和联合组Uu转阴率分别为54.3%(19/35),71.8%(56/78)和89.0%(113/127),联合组明显高于中、西药组(P均<0.05)。联合组、西药组和中药组的治愈率分别为25.2%、20.5%和20.0%,总有效率分别为89.0%、71.8%和54.3%,联合组与中药组比较差异具有统计学意义(P<0.05)。结论:宁泌泰胶囊联合盐酸多西环素片治疗Uu阳性的慢性前列腺炎比单用宁泌泰胶囊或盐酸多西环素片疗效好。Objective： To investigate the effects of Ningmitai Capsules（ NMT） combined with doxycycline hydrochloride（ DH） on chronic prostatitis induced by Ureaplasma urealyticum（ Uu）. Methods： This randomized controlled trial included 240 male patients with Uu-positive chronic prostatitis,treated orally with NMT at 4 capsules tid（ n = 35）,DH at 100 mg bid（ n = 78）,and NMT ＋ DH at the corresponding doses（ n = 127）,respectively,all for 2 successive weeks. At 1 week after drug withdrawl,we conducted routine urine analysis,EPS examination,and drug sensitivity test of the cultured Uu. Results： The positive-to-negative rate of Uu was significantly higher in the NMT ＋ DH group than in the NMT and DH groups（ 89. 0% [113 /127] vs 54. 3% [19 /35]and 71. 8% [56 /78],P〈0. 05）,so were the cure rate（ 25. 2% vs 20. 0% and 20. 5%,P〈0. 05） and total effectiveness rate（ 89. 0% vs 54. 3% and 71. 8%,P〈0. 05）. Conclusion： The combination of Ningmitai Capsules and doxycycline hydrochloride is more effective than either Ningmitai Capsules or doxycycline hydrochloride used alone in the treatment of Uu-positive chronic prostatitis.

关 键 词：宁泌泰胶囊 盐酸多西环素 联合用药 慢性前列腺炎 溶脲脲原体 

分 类 号：R697.33[医药卫生—泌尿科学]