慢性肌筋膜激痛点大鼠模型的剪切波弹性模量研究  

Study of shear wave elastic modulus in a rat model of chronic myofascial trigger points

作　　者：吕恒勇[1] 李真[1] 王月香[2] 李迎新[1] 吴金鹏[1] 

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所激光医学实验室,天津300192 [2]解放军总医院超声科,北京100853

出　　处：《中国临床解剖学杂志》2017年第1期57-61,共5页Chinese Journal of Clinical Anatomy

摘　　要：目的研究弹性超声在大鼠肌筋膜激痛点鉴定中的应用价值,为肌筋膜疼痛综合征等疾病的诊断研究提供依据。方法 24只雄性SD大鼠(7周龄),随机分成对照组和模型组,模型组采取钝性打击结合离心运动的实验方法对其进行连续8周的干预,造模结束后,模型组与对照组均正常饲养4周,12周结束后通过电生理检测技术进行模型鉴定,并对激痛点行超声检查,检测激痛点的剪切波弹性模量,进一步分析比较组间差异。结果模型组大鼠股内侧肌肌电表现出异常自发电位,证明激痛点的存在;激痛点病灶区的剪切波弹性模量明显高于临近区(P<0.05),且模型组激痛点病灶区与临近区组织弹性模量均高于对照组。结论剪切波弹性模量测量方法可以量化激痛点的硬度特征,且提示激痛点病灶区硬度显著增大,可为临床触诊提供客观依据,实现对病灶区与临近区的有效鉴别,为鉴定激痛点动物模型提供了一种新方法,对于肌筋膜激痛点相关疾病的临床诊断与疗效评价具有重要的研究与应用价值。Objective To detect the shear wave elastic modulus of the myofascial trigger points of chronic myofascial trigger points in a rat model, and study the application value of elastic ultrasound in the identification of the rat model and clinical diagnosis, and provide the basis for the diagnosis of the disease such as myofascial pain syndrome. Methods A total of 24 male SD rats（7 weeks old） were randomly divided into a control group（group A） and a model group（group B）. A blunt striking injury and eccentric exercise were applied to the rats in the model group for 8 weeks, and then all rats were fed normally for 4weeks. At the end of 12 weeks, EMG of rats was detected, and the elastic modulus of myofascial trigger point was measured by shear wave elastography and the difference between groups was compared. Results Spontaneous electrical activity was detected in rats of group B, showing the existence of myofascial trigger points. The shear wave elastic modulus in focal region of the trigger point was significantly higher than that of the surrounding tissue（P〈0.05）, and the elastic modulus of the focal region and the surrounding tissue of the rats in the model group was higher than that of the control group. Conclusion Shear wave elasticity modulus measurement technique can quantify stiffness characteristics of myofascial trigger point, and prompt significant increase of the hardness of the trigger points, providing objective basis for clinical diagnosis. This technique can also be used to differentiate focal region and the surrounding tissue, providing a new way to identify the myofascial trigger point of the rat model. Therefore, this technique has an important study and application value for clinical diagnosis and treatment effect evaluation of myofascial pain syndrome.

关 键 词：激痛点 弹性模量 超声弹性成像 

分 类 号：R312[医药卫生—基础医学]