婴幼儿反复喘息的危险因素研究  

Risk Factors for Infants and Toddlers with Recurrent Wheezing

作　　者：张景丽[1] 吴会芳[1] 赵倩[2] 王玉芳[3] 张中平[1] 

机构地区：[1]河北省儿童医院呼吸三科,河北省石家庄市050031 [2]河北医科大学第一医院儿科,河北省石家庄市050030 [3]河北省唐山市妇幼保健院小儿呼吸科,063000

出　　处：《中国全科医学》2017年第1期76-79,共4页Chinese General Practice

基　　金：河北省医学科学研究重点课题计划(20160429)

摘　　要：目的探讨婴幼儿反复喘息的危险因素。方法选取2015年河北省儿童医院、河北医科大学第一医院、唐山市妇幼保健院收治的由支气管肺炎引起的反复喘息婴幼儿453例,其中API阳性患儿152例(API阳性组),API阴性患儿301例(API阴性组);选取同期、同年龄在以上3个医院住院的支气管肺炎患儿318例作为对照组。采用回顾性分析法,通过查阅病历收集患儿的临床资料,包括性别、早产、超重/肥胖、生活环境及母孕期吸烟、应用抗生素及非甾体抗炎药情况。危险因素分析采用多因素Logistic回归分析。结果 3组年龄、性别间差异无统计学意义(P>0.05);而早产、超重/肥胖、生活环境及母孕期吸烟、应用抗生素及非甾体抗炎药间差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,早产、超重/肥胖、生活在城市及母孕期吸烟、应用抗生素及非甾体抗炎药是婴幼儿反复喘息的危险因素(P<0.05)。结论患儿早产、超重或肥胖、生活在城市及母亲孕期吸烟、应用抗生素及非甾体抗炎药,是婴幼儿反复喘息的危险因素。Objective To investigate the risk factors for recurrent wheezing in infants and toddlers.Methods Four hundred and fifty-three infants and toddlers with recurrent wheezing due to bronchopneumonia admitted to Children＇s Hospital of Hebei Province,the First Hospital of Hebei Medical University and Tangshan Maternal and Child Health Care Hospital,in 2015 were selected,and divided into positive API group（ n = 152）,and negative API group（ n = 301）.And other age-matched318 infants and toddlers with bronchopneumonia hospitalized in the 3 hospitals during the same period were selected as the control group.The clinical data of the children,including sex,premature birth,overweight / obesity,living environment,maternal smoking,maternal prescribing antibiotics and non-steroidal anti-inflammatory drugs during pregnancy were collected by checking the medical records and analyzed retrospectively.The risk factors for recurrent wheezing were analyzed by multivariate Logistic regression.Results There was no significant difference in age and sex between the 3 groups（ P〉0.05）.The differences in the ratio of premature birth,overweight / obesity,living environment,maternal smoking,maternal prescribing antibiotics and non-steroidal anti-inflammatory drugs during pregnancy demonstrated statistical significance（ P〈0.05）.Results of multivariate Logistic regression analysis showed that the risk factors for recurrent wheezing in infants and toddlers were premature birth,overweight / obesity,living in the city,maternal smoking,using antibiotics and non-steroidal anti-inflammatory drugs during pregnancy（ P〈0.05）.Conclusion Premature birth,overweight or obesity,living in the city and maternal smoking,use of antibiotics and non-steroidal anti-inflammatory drugs during pregnancy,are risk factors for recurrent wheezing in infants and toddlers.

关 键 词：婴儿 反复喘息 危险因素 

分 类 号：R543.5[医药卫生—心血管疾病]