云南省7934例农村育龄人群乙型肝炎病毒标记物血清学筛查检测结果分析  

Serologic screening for HBV among 7934 individuals of childbearing age in rural areas of Yunnan

作　　者：李根瑞 陈涓涓 谢正媛 李晔 吴天辉 张静蓉 赵子高 宝福凯[2] 

机构地区：[1]云南省人口和计划生育科学技术研究所,云南昆明650021 [2]昆明医科大学病原生物学与免疫学系

出　　处：《中国预防医学杂志》2017年第1期31-34,共4页Chinese Preventive Medicine

摘　　要：目的了解云南省三个县7 934例农村育龄人群乙肝表面抗原(HBsAg)阳性率和乙肝病毒感染状况,为干预措施提供科学依据。方法用ELISA法筛查云南省石屏县、大关县、西盟县7 934例血清样本,采用描述性流行病学研究方法分析育龄人群中HBsAg阳性率和乙肝病毒感染状况。结果三个县7 934例,HBsAg阳性人数463例,阳性率为5.84%,西盟县阳性率12.38%、大关县5.29%、石屏县3.33%,男性阳性率为7.33%,女性阳性率为4.90%,三县之间和男女性别之间差异有统计学意义。单独乙肝表面抗体(HBsAb)阳性1 646例,构成比20.75%,HBsAb阳性及合并其他阳性2 594例,构成比32.69%较全国流行率低。共出现HBV血清学标志物组合模式19种,其中排在前六位的是:HBsAg、HBsAb、乙肝e抗原(HBeAg)、乙肝E抗体(HBeAb)、乙肝核心抗体(HBcAb)均阴性,共4 772例,构成比为60.15%;HBsAb为阳性其余四项阴性,共1 646例,构成比为20.75%;HBsAb、HBeAb、HBcAb为阳性,HBsAg、HBeAg为阴性,共499例,构成比为6.29%;HBsAb、HBcAb为阳性,HBsAg、HBeAb、HBeAg为阴性,共367例,构成比为4.63%;HBsAg、HBeAb、HBcAb为阳性,HBsAb、HBeAg为阴性,共216例,构成比为2.72%;HBsAg、HBeAg、HBcAb为阳性,HBsAb、HBeAb为阴性,共133例,构成比为1.68%。结论准备怀孕的易感人群应当给予宣传教育,孕前接种乙肝疫苗;阳性人群要积极配合做好确诊和治疗等工作,从而预防和控制乙肝的传播。Objective To understand the serological characteristics of HBV among adults of childbearing age in rural areas of Yunnan Province. Methods A total of 7 934 adults were selected from Shiping, Daguan and Ximeng counties of Yunnan Province, serum samples were collected for the detection of HBV by ELISA. A de- scriptive epidemiological method was used for data analysis. Results The overall HBsAg positive rate was 5.84% （463/7 934）, it was 12.38% in Ximeng county, 5.29%in Daguan county and 3. 33% in Shiping coun- ty. The positive rate was higher in men than that in women （7.33% vs 4.90%, P〈0.05）. 1 646 subjects were positive for HBsAb and 2 594 individuals were also positive for other HBV markers, accounting for 32.69%, which was lower than the national average. There were 19 kinds of HBV serological marker combinations, in- cluding negative HBsAg, HBsAb, HBeAg, HBeAb and HBcAb, accounting for 60.15% positive HBsAb with all others negative, accounting for 20.75%; positive HBsAb, HBeAb, HBcAb and negative HBsAg, HBeAg, accounting for 6.29%; positive HBsAb, HBcAb and negative HBsAg, HBeAb, HBeAg, accountingfor 4.63% ; positive HBsAg, HBeAb, HBcAb and negative HBsAb, HBeAg, accounting for 2.72%; positive HBsAg, HBeAg, HBcAb and negative H BsAb, HBeAb, accounting for 1.68%. There were significant differ- ence of HBsAg positive rate among adults from three counties and between men and women. Conclusions It is very important to have HBV serological screening for adults at childbearing age, especially for those plan ning to have a baby. HBV vaccination should be enhanced for women with negative HBsAb and individuals who are HBV positive should be treated as early as possible in order to prevent and control the spread of HBV.

关 键 词：育龄人群 乙型肝炎 流行 云南省 

分 类 号：R512.62[医药卫生—内科学]