对二茂铁苯甲酰噻二唑类化合物的合成和性质研究  

Synthesis and Properties of 4-Ferrocenyl-benzoyl-thiadiazole Derivatives

作　　者：任亚平[1] 刘絮[1] 王瑞 周元清[1] 李标[1] 徐琰[1] 宋毛平[1] 

机构地区：[1]郑州大学化学与分子工程学院,郑州450001 [2]定州英才实验中学,定州073000

出　　处：《有机化学》2017年第1期110-115,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21171149)资助项目~~

摘　　要：以对二茂铁苯甲酸和2-氦基-5-芳基-1,3,4-噻二唑化合物为原料,合成了7个新的二茂铁苯甲酰噻二唑化合物FcL_1~FcL_7.采用IR、~1H NMR和元素分析对化合物进行了表征.用X-Ray单晶衍射测定了化合物FcL_4的晶体结构.电化学研究表明,化合物在电极表面发生可逆的单电子转移,FcL_1~FcL_7对Pb^(2+)和Zn^(2+)都有一定的电化学响应.抗菌活性试验表明FcL_1~FcL_7均对玉米禾谷镰刀菌有较好的抑菌活性和选择性.抗癌活性试验表明FcL_5~FcL_7对人体食管癌细胞的抑制作用明显.Seven kinds of ferrocenyl-benzoyl-thiadiazole compounds FcL_1~FcL_7 were synthesized by using 4-ferrocenylbenzoic and 2-amino-5-aryl-1,3,4-thiadiazole as raw materials.These compounds were characterized by IR,~1H NMR and elemental analysis.The crystal structure of FcL_4 was determined by X-ray diffraction analysis.The electrochemical research showed that the redox reaction on the surface of electrode was reversible with single electron,and FcL_1~FcL_7 have a certain redox response to Pb^（2＋） and Zn^（2＋）.The antibacterial activity tests indicated that FcL_1~FcL_7 presented significant activity and selectivity against Fusarium graminearum.FcL_5~FcL_7 exhibited good inhibition against human esophageal cancer cells in the anticancer activity tests.

关 键 词：二茂铁 噻二唑 单晶结构 电化学性质 生物活性 

分 类 号：O626[理学—有机化学]