内蒙古自治区2015年疑似预防接种异常反应监测分析  

Study on the surveillance of adverse event following immunization in Inner Mongolia,2015

作　　者：赵润毛 范耀春[2] 武贵森[2] 闫绍宏[2] 

机构地区：[1]包头医学院研究生学院,内蒙古014040 [2]内蒙古疾病预防控制中心

出　　处：《医学动物防制》2017年第2期119-121,125,共4页Journal of Medical Pest Control

基　　金：国家卫生和计划生育委员会/WHO/UNICEF加强西部地区麻疹监测项目(WPCHN1206297)

摘　　要：目的分析内蒙古自治区2015年疑似预防接种异常反应(AEFI)发生特征,评价AEFI监测系统运转情况和预防接种的安全性。方法通过AEFI信息管理系统收集2015年内蒙古自治区AEFI监测数据,采用描述流行病学方法进行分析。结果内蒙古自治区2015年共报告AEFI个案2 381例,其中一般反应占95.46%,异常反应占4.03%,偶合症占0.46%,待定占0.04%。AEFI报告数集中在3~8月,7月最多。报告中<1岁年龄组报告数最多,其中8月龄和9月龄较多。88.87%的个案在接种后的24 h内发生反应,症状以发热/红肿/硬结为主。报告发生率最高的为百白破(无细胞)疫苗。结论内蒙古自治区AEFI监测各项指标符合国家要求,但数据存在地区间的不平衡性,应加强培训和督导以提高监测质量;AEFI监测的敏感性较高;AEFI常发生在小年龄组儿童和接种后24 h内。Objective The study is to analyze the occurrence features of adverse event following immunization（AEFI） in Inner Mongolia, 2015, and to evaluate the implementation of AEFI information management system, and the immunization safety re- lated to vaccines. Methods 2015 AEFI data were collected through the national AEFI information management system, and ex- ported through the Excel. The descriptive methodology was used in the study. Results 2 381 AEFI cases occurring in 2015 were reported, of which common adverse reactions accounted for 95.46% , abnormal reactions accounted for 4.03% , coincidental e- vents accounted for 0. 46%, undetermined reactions accounted for 0.03%. The AEFI cases concentrated in March to August, the peak appeared in July. The cases more often occurred in children who are not yet 1 year old, especially in 8 - month - old and 9 -month -old children. There are 88. 87% of cases who occurred on the day of vaccination and 1 day after vaccination, and the main clinical symptoms were fever, red, swollen and scleroma. DPT （ cell - free ） has the highest incidence rate of AEFI. Conclusion The indexes of Inner Mongolia AEFI surveillance system can meet the requirements of MOH. The results show the safety of NIP vaccines is satisfactory, but the da-ta has large variations between regions. The results suggest that the related training and monitoring should be strengthened so as to improve the quality of surveillance system. The sensitivity of national AEFI surveillance is relatively good. AEFIs often occurred in young children, and within 1 day after vaccination.

关 键 词：疑似预防接种异常反应 监测 

分 类 号：R186[医药卫生—流行病学]