血清IgG4和IgE在儿童过敏性哮喘和过敏性鼻炎中的应用  

Application of serum IgG4 and IgE in children with allergic asthma and rhinallergosis

作　　者：罗星星[1] 陈展泽[1] 许扬扬[1] 区文华[1] 麦智广[2] 李炜煊[1] 

机构地区：[1]广东省佛山市第一人民医院检验科,528000 [2]广东省佛山市第一人民医院儿科,528000

出　　处：《国际检验医学杂志》2017年第4期442-443,446,共3页International Journal of Laboratory Medicine

基　　金：广东省佛山市卫生和计生局医学科研课题资助项目(20160089)

摘　　要：目的通过对过敏性哮喘和过敏性鼻炎患儿进行血清免疫球蛋白(Ig)G4和IgE检测,为儿童过敏性哮喘和过敏性鼻炎的诊断、治疗和预防提供重要实验室依据。方法对118例过敏性哮喘、167例过敏性鼻炎儿童患者及150例同期健康体检儿童(对照组)进行血清IgG4和IgE水平的检测。结果过敏性哮喘组和过敏性鼻炎组患儿的血清IgG4和IgE水平均显著高于对照组,差异有统计学意义(P<0.05)。过敏性哮喘组和过敏性鼻炎组组内比较,血清IgG4的阳性率均比IgE高,差异有统计学意义(P<0.05);血清IgG4和IgE联合检测在过敏性哮喘组和过敏性鼻炎组中的阳性率均比单独指标检测的阳性率高,差异有统计学意义(P<0.05)。过敏性哮喘组的血清IgG4阳性率低于过敏性鼻炎组,差异有统计学意义(P<0.05)。过敏性哮喘组的血清IgE阳性率低于过敏性鼻炎组,差异无统计学意义(P>0.05)。结论血清IgG4和IgE检测对儿童过敏性哮喘和过敏性鼻炎的诊治和病情监测具有一定的临床意义。Objective To detect serum IgG4 and IgE levels in children with allergic asthma and rhinallergosis to provide an important laboratory evidence for its diagnosis,treatment and prevention.Methods The serum IgG4 and IgE levels were detected in118 children patients with allergic asthma,167 children patients with rhinallergosis and 150 healthy children（control group）undergoing physical examination in the same period.Results The levels of serum IgG4 and IgE in the allergic asthma group and rhinallergosis group were significantly higher than those in the control group,the difference was statistically significant（P〈0.05）.In the intra-group comparison of the allergic asthma group and rhinallergosis group,the positive rate of serum IgG4 was higher than that of serum IgE,the difference was statistically significant（P〈0.05）.The positive rate of joint detection of serum IgG4 and IgE in these two groups was higher than that of single index detection,the difference was statistically significant（P〈0.05）.The positive rate of serum IgG4 in the allergic asthma group was lower than that in the rhinallergosis group,the difference was statistically significant（P〈0.05）.The positive rate of serum IgE in the allergic asthma group was lower than that in the rhinallergosis group,but the difference was not statistically significant（P〉0.05）.Conclusion Serum IgG4 and IgE have a certain clinical significance in the occurrence,treatment and surveillance of allergic asthma and rhinallergosis in children.

关 键 词：过敏性哮喘 过敏性鼻炎 儿童 

分 类 号：R725.6[医药卫生—儿科] R765.21[医药卫生—临床医学] R446.6