冠心病患者发病48h内同型半胱氨酸、血管性血友病因子和组织因子促凝活性的检测分析  

Analysis on detection of Hcy,vWf and TF-PCA within 48 h of onset in patients with coronary heart disease

作　　者：刘俊[1] 杜丹心 刘佳[1] 张明洁[1] 

机构地区：[1]武汉科技大学附属天佑医院检验科,430064

出　　处：《国际检验医学杂志》2017年第4期483-484,487,共3页International Journal of Laboratory Medicine

摘　　要：目的观察血清同型半胱氨酸(Hcy)、血浆血管性血友病因子(vWF)及全血组织因子促凝活性(TF-PCA)在冠心病(CHD)患者发病48h内的变化。方法采用相关仪器对300例CHD患者及100例健康体检者的血清Hcy、血浆vWF及全血TF-PCA水平进行检测和统计学分析。300例CHD患者分为稳定型心绞痛组(SAP组,n=96),不稳定型心绞痛组(UAP组,n=100)和急性心肌梗死组(AMI组,n=104)。结果 CHD患者Hcy、vWF及TF-PCA水平均高于对照组,差异有统计学意义(P<0.05);Hcy水平AMI组>UAP组>SAP组,差异有统计学意义(P<0.05);AMI组及UAP组vWF及TF-PCA水平较SAP组增高,差异有统计学意义(P<0.05)。伴糖尿病、高血压的SAP、UAP及AMI患者较未伴糖尿病、高血压同组患者Hcy水平均有明显增高,差异有统计学意义(P<0.05);UAP组及AMI组vWF及TF-PCA水平比较差异有统计学意义(P<0.05)。结论常规检测Hcy、vWF及TF-PCA对CHD患者疾病的诊断及疗效的观察均有较为重要的临床价值。Objective To observe the change of serum homocysteine（Hcy）,plasma von willebrand factor（vWF）and whole blood tissue factor procoagulant activity（TF-PCA）within 48 hof onset in the patients with coronary heart disease（CHD）.Methods The relevant instrument was adopted to detect the level of serum Hcy,plasma vWF and whole blood TF-PCA in 300 CHD patients and 100 individuals undergoing the healthy physical examination,and then the statistical analysis was performed.Three hundreds cases of CHD were divided into the stable angina group（SAP group,n=96）,unstable angina group（UAP group,n=100）and acute myocardial infarction group（AMI group,n=104）.Results The Hcy,vWF and TF-PCA levels in the CHD patients were higher than those in the control group,the difference was statistically significant（P〈0.05）.The Hcy level：the AMI group〉UAP group 〉SAP group,the difference was statistically significant（P〈0.05）.The vWF and TF-PCA levels in the AMI group and UAP group were higher than those in the SAP group with statistical difference（P〈0.05）.The Hcy level in SAP,UAP and AMI patients complicated with diabetes and hypertension was significantly increased compared with the patients without complicating diabetes and hypertension,the difference was statistically significant（P〈0.05）.The vWF and TF-PCA levels had statistical difference between the UAP group and AMI group（P〈0.05）.Conclusion Routinely detecting the levels of Hcy,vWF and TF-PCA has an important clinical value for the diagnosis and curative effect observation in the patients with CHD.

关 键 词：急性心肌梗死 稳定型心绞痛 同型半胱氨酸 血管性血友病因子 组织因子促凝活性 

分 类 号：R541.4[医药卫生—心血管疾病] R446.1[医药卫生—内科学]