磁共振灌注加权成像在糖尿病脑损害中的应用进展  

Progress of PWI' application in the brain damage of diabetes

作　　者：王善诚 李澄[2] 瞿航 杜芳[1] 

机构地区：[1]扬州市第一人民医院(扬州大学第二临床医学院)医学影像科,扬州225001 [2]东南大学附属中大医院放射科,南京210000

出　　处：《磁共振成像》2017年第2期155-160,共6页Chinese Journal of Magnetic Resonance Imaging

摘　　要：糖尿病脑损害是糖尿病于中枢系统的并发症,脑灌注的异常是糖尿病脑损害的表现之一。磁共振灌注成像分为动态磁敏感对比增强、动态增强磁共振成像和动脉自旋标记3类,能够反映脑血流灌注等信息。随着磁共振灌注成像技术的不断发展,可以更早期、全面、准确地测量脑部微循环的改变及其所带来的中枢神经系统损害,特别是动脉自旋标记成像,作为非侵入性磁共振灌注成像技术,可以定量并重复测量脑血流量,更有效避免了使用外源性对比剂带来的风险,已逐渐成为糖尿病脑损害研究的有力工具。本文将围绕磁共振灌注成像在糖尿病脑损害中的研究与应用展开综述。Diabetic brain damage is a complication of diabetes in the central nervous system. The brain perfusion abnormalities is one of the manifestations of diabetic brain damage. Magnetic resonance perfusion imaging（PWI） can reflect the information of microcirculation, is divided into three categories, which are dynamic susceptibility contrast enhancement（DSC）, dynamic contrast enhancement（DCE） and arterial spin labeling（ASL）. With the development of magnetic resonance perfusion imaging, we get more early, comprehensive and accurate measurement of changes in the brain’s microcirculation. Especially, the ASL is a noninvasive method of PWI, it can be a quantitative and repeated way to meansure cerebral blood flow（CBF） and can avoid the risks bring by exogenous contrast agent effectively. ASL has been a powerful tool in diabetic research. This paper focuses on the research and application of PWI in the brain damage of diabetes.

关 键 词：糖尿病脑损害 糖尿病脑病 糖尿病并发症 磁共振成像 磁共振灌注成像 动脉自旋标记 

分 类 号：R445.2[医药卫生—影像医学与核医学] R587.2[医药卫生—诊断学]