骨碎补活性单体成分调控骨质疏松症相关信号通路的研究进展  

Research progress of the active monomer composition of rhizoma drynariae in the regulation of osteoporosis-related signaling pathways

作　　者：招文华 沈耿杨[1] 任辉[1] 丘婷[1] 张志达[1] 唐晶晶[2] 陈康[2] 梁德[2] 姚珍松[2] 杨志东[2] 江晓兵[2] 

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《中国骨质疏松杂志》2017年第1期122-129,140,共9页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81503591);国家中医临床研究基地业务建设第二批科研专项(JDZX2015078);广东省科学技术厅项目(2014A020221021);广东省自然科学基金(1614050002812);广东省自然科学基金(2014A030310082);广东省教育厅学科建设专项基金(育苗工程)[2013LYM-0012];广州中医药大学优秀青年学者科研基金项目(KAB110133K04);广州中医药大学第一附属医院创新强院项目(2015QN03);广州中医药大学第一临床优博论文培育项目(YB201501)

摘　　要：骨质疏松症相关分子信号通路的发现及其各通路中关键靶点的明确,为骨质疏松症的防治开辟了新的方向。骨碎补是防治骨质疏松症的一味常用中药,目前骨碎补中被证明具有抗骨质疏松活性的单体成分包括柚皮苷、柚皮素和新北美圣草苷。研究显示,骨碎补通过调控骨代谢相关分子信号通路,如OPG/RANKL/RANK通路、组织蛋白酶K通路、Wnt/β-catenin通路、骨形成蛋白通路上相关靶点,发挥抑制骨吸收或促进骨形成的作用,最终达到防治骨质疏松症的目的。本文综述了骨碎补活性单体成分调控骨质疏松症相关信号通路的研究进展,发现研究者使用的干预药物以骨碎补总黄酮为主,其次是单体成分柚皮苷,尽管有研究表明柚皮素及新北美圣草苷可能比柚皮苷具备更强的抗骨质疏松活性,但相关研究较匮乏。另外,目前相关研究仅停留在单一分子信号通路中的一个或数个调控靶点上,为了阐明骨碎补活性单体成分抗骨质疏松的多靶点、多环节生物学机制,发掘中药防治骨代谢疾病的潜在价值,今后有必要进行骨碎补活性单体成分的进一步分离、鉴定以及各信号通路间的相互交联研究。As the relevant molecular signaling pathways in osteoporosis are discovered and their key targets in each path are clear,it has opened a newdirection for the prevention and treatment of osteoporosis. Rhizoma drynariae is widely used for the prevention and treatment of osteoporosis. It has been proved that the active monomer composition of rhizoma drynariae,including naringin,naringenin,and neoeriocitrin,has the anti-osteoporosis activity. Studies reveal that rhizoma drynariae regulates targets of signaling pathways,such as OPG / RANKL / RANK,CTSK,Wnt / β-catenin,and BMP pathways in bone metabolism,inhibits the bone resorption or stimulates the bone formation,and finally achieves the goal of prevention and treatment of osteoporosis. In this paper,research progress of the active monomer composition of rhizoma drynariae in the regulation of relevant signaling pathways is reviewed. We find that drug intervention is mainly given with total flavonoids in rhizoma drynariae,followed by naringin. Although some studies showthat naringenin and neoeriocitrin may have stronger anti-osteoporosis activity than naringin,relevant research is scarce. In addition,the current related research only focuses on one or several targets of single molecular signaling pathway. To clarify the multi-target and multi-link anti-osteoporosis biological mechanism of the active monomer composition of rhizoma drynariae and to explore the potential value of traditional Chinese medicine in the prevention and treatment of bone metabolic diseases,in the future there is a need of further isolation and identification of active monomer composition of rhizoma drynariae and research in crosstalk between different signaling pathways.

关 键 词：中医中药 骨碎补 活性单体成分 骨质疏松症 分子信号通路 生物学机制 

分 类 号：R68[医药卫生—骨科学]