阿仑膦酸钠联合营养运动干预用于绝经后骨质疏松症的疗效  

Efficacy of alendronate sodium combined with dietary and exercise intervention in postmenopausal osteoporosis

作　　者：高静[1] 毛春英[1] 章建霞 金辉[1] 封育瑾 饶逍骏 

机构地区：[1]衢州市人民医院营养科

出　　处：《中国生化药物杂志》2017年第1期163-164,168,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 观察阿仑膦酸钠联合营养运动干预用于绝经后骨质疏松症的疗效。方法 88例在门诊进行药物治疗的绝经后骨质疏松症妇女给予阿仑膦酸钠和维生素D制剂,同时联合营养运动干预,在治疗前及治疗后12个月分别测定腰部和骨股颈骨密度（bone mineral density,BMD）水平。结果 药物治疗同时联合营养运动干预12个月后腰部和股骨颈BMD水平显著高于治疗前,血清骨碱性磷酸酶（bone alkaline phosphatase,BLAP）、碱性磷酸酶（alkaline phosphatase,AKP）、抗酒石酸酸性磷酸酶（tartrate resistant acid phosphatase,TRACP）浓度显著低于治疗前,差异均有统计学意义（P〈0.05）。结论 在药物治疗的基础上联合营养运动干预能更好地提高药物疗效和骨密度水平。Objective To evaluate the efficacy of alendronate sodium combined with dietary and exercise intervention in postmenopausal osteoporosis. Methods 88 postmenopausal osteoporosis patients were enrolled and treated with alendronate sodium and Vitamin D combined with dietary and exercise intervention for 12 months. Bone mineral density （BMD） of lumber spine and femur neck were measured before and after the treatment. Results Medication combined with dietary and exercise intervention significantly increased bone mineral density of postmenopausal osteoporosis patients, and the serum levels of bone alkaline phosphatase （BLAP）, alkaline phosphatase （AKP） and tartrate resistant acid phosphatase （TRACP） were significantly higher than those pre-treatment, with significant differences （P〈0.05）. Conclusion Compared to simple medication treatment, medication combined with dietary and exercise intervention is more effective to enhance medication efficacy and BMD level.

关 键 词：骨质疏松症 绝经后 阿仑膦酸钠 营养运动干预 

分 类 号：R681[医药卫生—骨科学]