生血宁片和琥珀酸亚铁片治疗妊娠合并贫血患者的疗效比较  

Comparison the effect of Shengxuening tablets and ferrous succinate in treating pregnancy with anemia

作　　者：张锋[1] 周夫群[1] 尉伟东[1] 

机构地区：[1]绍兴市妇幼保健院妇一科

出　　处：《中国生化药物杂志》2017年第2期68-71,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的对比分析生血宁片和琥珀酸亚铁片治疗妊娠期贫血患者的临床疗效及安全性。方法选择2015年3月～2016年2月绍兴市妇幼保健院收治的早期妊娠合并贫血患者212例,按照就诊顺序编号,采用数字随机表法将患者分为A组和B组,每组106例,A组采用生血宁片治疗,B组采用琥珀酸亚铁片治疗,2组患者均进行相同方案的营养饮食指导,2组均连续治疗3个月。每位患者随访至分娩结束,统计2组患者妊娠治疗结束后至妊娠结束前再次贫血情况及妊娠结局情况并比较。比较2组患者治疗前、治疗后1、2、3个月血红蛋白（Hb）水平、红细胞计数（RBC）、血清铁蛋白（SF）、总铁结合率（TIBC）变化情况;比较2组患者治疗期间3次随访Hb、RBC、SF、TIBC指标回复正常水平的时间和治疗后临床疗效,观察患者药物不良反应。结果 2组患者治疗后1、2、3个月Hb、RBC、SF水平均明显高于治疗前、TIBC低于治疗前（P〈0.05）,治疗1、2个月后,B组患者Hb、RBC、SF明显高于A组,TIBC明显低于A组（P〈0.05）,2组治疗3个月后Hb、RBC、SF、TIBC均恢复正常水平,组间比较差异无统计学意义。B组Hb、RBC、SF、TIBC指标恢复正常水平时间明显短于A组（P〈0.05）。治疗3个月后,2组临床疗效比较差异无统计学意义,治疗期间B组患者药物不良反应率明显高于A组（P〈0.05）。治疗结束至妊娠结束前,A组患者5例再次出现贫血并行治疗,B组患者11例再次贫血并治疗,2组患者妊娠结局比较,A组妊娠不良率高于B组（P〈0.05）。结论生血宁片和琥珀酸冶铁治疗早期妊娠贫血各有优缺点,临床可考虑联合应用治疗妊娠贫血,提升临床疗效和安全性。Objective To compare the clinical efficacy and safety of anemia during pregnancy of Shengxuening tablets and ferrous succinate treatment for clinical treatment in patients with anemia.Methods 212 cases of pregnancy in early pregnancy patients with anemia from March 2015 to February 2016 in our hospital,numbered according to the order of treatment,were randomly divided the patients into group A and group B,106 cases in each group,group A with Shengxuening tablets treatment,group B with ferrous succinate tablets treatment,two groups of patients were treated with the same program of diet guidance,all patients were treated for three months.Each patient was followed up to the end of delivery,and the two groups of patients before and after pregnancy treatment to the end of pregnancy anemia and pregnancy outcomes were compared.Comparison of two groups of patients before and after treatment for one,two and three months of hemoglobin（Hb） level,red blood cell count（RBC）,serum ferritin（SF）,total iron binding rate（TIBC） changes;finishing treatment of the two groups during the three follow-up of Hb,RBC,SF TIBC,which returned to normal levels at the time and,after three months of treatment and evaluate the clinical efficacy of the two groups were collected and compared during the treatment of adverse drug reactions of two groups were compared.Results After treatment for one,two and three months,levels of Hb,RBC and SF in two groups of patients were significantly higher than those before treatment,TIBC was lower than that before treatment（P〈0.05）;After treatment for one and two months,RBC,SF and Hb in group B were significantly higher than those in group A,TIBC lower than group A（P〈0.05）;After treatment for three months,the levels of Hb,RBC,SF and TIBC in two groups were back to normal,and there was no significant difference between the two groups.Hb,RBC,SF,TIBC index recovery time of group B was significantly shorter than the group A（P〈0.05）.After treatment for three months,there was no signif

关 键 词：妊娠贫血 生血宁片 琥珀酸亚铁 疗效安全性 对比研究 

分 类 号：R714.254[医药卫生—妇产科学]