三联疗法联合中药治疗幽门螺杆菌所致消化性溃疡的临床疗效  

Effect of triple therapy plus traditional Chinese medicine in peptic ulcer caused by Helicobacter pylori

作　　者：叶洁桐[1] 任玲玲[1] 王昌雄[1] 

机构地区：[1]浙江省丽水市人民医院消化内科

出　　处：《中国生化药物杂志》2017年第2期133-135,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的评价三联疗法联合中药治疗幽门螺杆菌（Hp）所致消化性溃疡（peptic ulcer,PU）的临床疗效。方法选取148例Hp阳性PU患者,将其按照随机数字法随机分为研究组和对照组（74例/组）,对照组给予三联疗法（奥美拉唑＋克拉霉素＋阿莫西林）进行治疗,研究组在对照组基础上给予疏肝清热、健脾化瘀汤进行治疗,2组均以4周为1个疗程。比较2组治疗前后临床症状改善情况,疗程结束后4周记录Hp转阴率,并对治疗后的临床疗效和治疗期间的不良反应进行评价。结果治疗后2组中医症候总积分均显著下降（P〈0.05）,但研究组下降更为明显（P〈0.05）。研究组总有效率为95.95%显著性高于对照组为79.73%（P〈0.05）。研究组胃镜溃疡总有效率为93.24%显著性高于对照组的75.67%（P〈0.05）。研究组Hp转阴率为82.43%,显著性高于对照组为64.86%（P〈0.05）。研究组不良反应发生率为12.16%,对照组为9.46%,2组相比差异无统计学意义。结论三联疗法联合中药能明显改善Hp所致PU患者的临床症状,提高临床疗效,增强Hp清除率,并且安全可耐受。Objective To discuss the effect of triple therapy plus traditional Chinese medicine in the treatment of peptic ulcer（PU） caused by Helicobacter pylori（Hp）.Methods 148 cases with PU were randomly divided into study group and control group of 74 cases in each group.The control group were treated with triple therapy（omeprazole ＋ clarithromycin ＋ amoxicillin）,and the study group were given liver-discharging and heat-clearing and invigorating spleen and removing blood stasis decoction,additionally.Both groups received treatment for one course of 4 weeks.The changes of clinical symptoms,negative conversion ratio of Hp and adverse reaction were compared.Results The scores of clinical symptoms were all significantly decreased in both two groups after treatment（P〈0.05）,but the study group changed more than control group（P〈0.05）.The total effective rate was95.95%,rather higher than 79.73% in control group（P〈0.05）.The negative conversion ratio of Hp was 82.43%,obviously higher than 64.86% in control group（P〈0.05）.The incidence of adverse reaction was 12.16% in study group,similar to 9.46% in control group.Conclusion Triple therapy plus traditional Chinese medicine can significantly improve the clinical symptoms,clinical effect and negative conversion ratio of Hp,and has a good safety and tolerability.

关 键 词：三联疗法 中药 消化性溃疡 幽门螺杆菌 

分 类 号：R656.62[医药卫生—外科学]