小儿哮喘非急性发作期IgE、EOS、LTE-4含量的变化及其临床意义  

Research on the IgE,EOS,LTE-4 content and its clinical significance with the inacute phase of pediatric asthma

作　　者：龚君芳[1] 王春燕[1] 陈娇磊 

机构地区：[1]义乌市中心医院儿科

出　　处：《中国生化药物杂志》2017年第2期300-301,304,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的通过检测小儿哮喘非急性发作期患儿血清免疫球蛋白（total immunoglobulin E,IgE）、外周血嗜酸性粒细胞（eosinphils,EOS）和尿白三烯E4（leukotr iene E4,LTE-4）水平,探讨其临床意义。方法选取2014年3月～2015年3月义乌市中心医院收治的90例小儿哮喘非急性发作期患者,根据患者的病情严重程度分成3组：一般哮喘组（n=32）、中度哮喘组（n=31）和重度哮喘组（n=27）,同时以30例正常儿童作为对照组。根据患者的病情给予每位患者不同剂量的β2受体激动剂（LABA）作为单药治疗,适当给予吸入糖皮质激素（inhaled corticosteroid,ICS）作为联合治疗使用。LABA的使用为3～4次/天。治疗3个月后,对患者进行疗效评估,并检测患儿IgE、EOS、LTE-4水平。结果经过3个月的治疗,3组小儿哮喘患者IgE、EOS、LTE-4水平均较治疗前明显下降（P〈0.05）,患者病情基本好转,3组疗效比较差异无统计学意义。结论血清IgE、EOS、LTE-4水平检测对小儿哮喘非急性发作期患者的临床症状具有评估意义;治疗过程中,血清IgE、EOS、LTE-4检测呈下降趋势,能够很好的指示小儿哮喘非急性发作期患者的健康恢复情况。Objective To explore the clinical significance of total serum immunoglobulin（IgE）,peripheral blood eosinophils（EOS） and urinary leukotriene E4（LTE-4） detection on pediatric asthma clinical symptoms of the inacute phase.Methods 90 cases with pediatric asthma clinical symptoms of the inacute phase from March 2014 to March 2015 were selected as experimental group,and divided into the general asthma group（n=32）,the moderate asthma group（n=31）,the sereval asthma group（n=27） and another 30 health children as control group.Give each patients children doses of β_2 agonists（LABA） as monotherapy,and inhaled corticosteroids（ICS） used as combination therapy.The use of LABA is 3-4 times/d.After three months＇ treatment,clinical efficacy were evaluated,and IgE,EOS,LTE-4 content were detected.Results After 3 months＇ treatment,IgE,EOS,LTE-4 contents in three experiment groups were significantly decreased（P〈0.05）,improved to the basic condition compared to control groups.The clinical efficacy among three groups had no significant differences.Conclusion IgE,EOS,LTE-4 levels detection of patients with pediatric asthma clinical symptoms of the inacute phase had evaluation significance,can be a good indicator of pediatric asthma health recovery in patients of the inacute phase.

关 键 词：小儿哮喘非急性发作期 血清总免疫球蛋白 外周血嗜酸性粒细胞 尿白三烯E4 

分 类 号：R72[医药卫生—儿科]