包茎松凝胶质量控制的研究  

Study on the quality control of Baojingsong Hydrogels

作　　者：曹博群 岳中瑾[2] 刘铭佩[2] 焦海胜[2] 贾晨[1] 刘玉亭[1] 

机构地区：[1]兰州大学药学院,兰州730000 [2]兰州大学第二医院药学部,兰州730030

出　　处：《西北药学杂志》2017年第2期201-205,共5页Northwest Pharmaceutical Journal

摘　　要：目的制备包茎松凝胶,完善包茎松凝胶的质量控制方法。方法采用HPLC法同时测定红霉素和倍他米松的含量。色谱柱:Agilent C_(18);流动相:0.025mol·L^(-1) KH_2PO_4-乙腈(70∶30);流速:1.0mL·min^(-1);检测波长:220nm;柱温:35℃;进样量:20μL。结果倍他米松的线性方程为Y=18.564 X-18.68(r=0.999 3),线性范围:8.6~172μg·mL^(-1);红霉素的线性方程为Y=0.112 5 X-9.87(r=0.995 2),线性范围:150.35~3 007μg·mL^(-1)。结论该方法重复性好,方法可行,能有效控制该制剂的质量。Objective To prepare Baojingsong Hydrogels and study the quality control method.Methods HPLC was used for the content determination of erythromycin and betamethasone at the same time.The determination was performed on an Agilent C（18） column with mobile phase consisted of 0.025mol·L^-1 KH2PO4-acetonitrile（70∶30）at the flow rate of 1.0mL·min^-1.The detection wavelength was set at 220 nm,and the column temperature was 35 ℃.The sample size was 20μL.Results The linear equation of betamethasone was Y=18.564 X-18.68（r=0.999 3）,and the linear range was 8.6-172μg·mL^-1.The linear equation of erythromycin was Y=0.112 5 X-9.87（r=0.995 2）,and the linear range was 150.35-3 007μg·mL^-1.Conclusion The method is reproducible and feasible,and can effectively control the quality of this medicine.

关 键 词：倍他米松 红霉素 包茎松凝胶 高效液相色谱法 质量控制 

分 类 号：R94[医药卫生—药剂学]