子宫腺肌病中医证候与MMP-9相关性研究  

Correlation Research on the TCM Symptoms of Aenomyosis and MMP-9

作　　者：李文君[1] 马红静[1] 

机构地区：[1]唐县人民医院,河北唐县072350

出　　处：《河南中医》2017年第1期137-138,共2页Henan Traditional Chinese Medicine

摘　　要：目的:探讨子宫腺肌病(adenomyosis,AM)中医证候与基质金属蛋白酶(matrix metalloprotein-9,MMP-9)的相关性。方法:选择子宫腺肌病患者60例为AM组,选择因子宫肌瘤行子宫全切术患者60例作为对照组,上述两组患者根据临床表现分为气滞血瘀证、寒凝血瘀证、热郁血瘀证、肾虚血瘀证4个证型,同时给予中医证候评分、MMP-9测定。结果:AM组MMP-9水平明显优于对照组,差异具有统计学意义(P<0.05),AM组中,气滞血瘀证均优于寒凝血瘀证、热郁血瘀证、肾虚血瘀证等证,差异具有统计学意义(P<0.05)。两组患者各证候均与MMP-9有明显的相关性(P<0.001),其中气滞血瘀证相关性强于其他组。结论:气滞血瘀证是子宫腺肌病最普遍最多见的中医证候。Objective ：To explore the correlation between the TCM symptoms of adenomyosis （AM） and MMP-9. Methods ： Totally 60 cases with AM were selected as AM group ,and 60 cases with AM undergone total hysterectomy were selected as control group. The syndrome of the above patients in both groups include ： qi stagnation and blood stasis syndrome, cold congealing and blood sta- sis syndrome,heat accumulation and blood stasis syndrome, kidney deficiency and blood stasis syndrome. The scores of the TCM symptoms and MMP-9 were determined. Results：The level of MMP-9 in AM group was obviously better than that in control group; the difference had statistical significance（P 〈 O. 05 ）. In AM group,the scores of qi stagnation and blood stasis syndrome were bet- ter than these of other three syndromes, with statistical difference（ P 〈 0.05 ）. There were apparent correlation between each symp- tom and MMP-9 （P 〈 0. 001 ） ,and among them the correlation in qi stagnation and blood stasis syndrome was better than that in other groups. Conclusion ：Qi stagnation and blood stasis syndrome is the most commonly seen TCM symptoms in AM.

关 键 词：子宫腺肌病 MMP-9 中医证候 

分 类 号：R271.911[医药卫生—中西医结合]