Megsin基因3个多态性位点与亚洲人群IgA肾病易感性关联的Meta分析  

Meta-analysis of the relevance between Megsin rs1055901,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population

作　　者：葛雅婷 苏美玲[2] 宋佳治[1,2] 熊祖应[1,2] 侯霜[2] 

机构地区：[1]安徽医科大学北京大学深圳医院临床学院,广东深圳518000 [2]北京大学深圳医院肾内科,广东深圳518000

出　　处：《重庆医学》2017年第5期648-650,653,共4页Chongqing medicine

基　　金：深圳市科技研发资金(JCYJ20140415162543010)

摘　　要：目的通过Meta分析评估亚洲人群Megsin基因3个多态性位点(rs1055901、rs1055902和rs2689399)与IgA肾病易感性的关联。方法通过中国知网、维普、万方数据库、中国生物医学文献数据库、PubMed、Web of Science和Google学术数据库数据库,电子检索关于亚洲人群Megsin基因rs1055901、rs1055902和rs2689399多态性位点与IgA肾病相关性的研究,检索年限为1960年1月1日开始至2016年5月2日。采用Stata12.0软件计算合并比值比(OR)和95%置信区间(CI),并进行敏感性及发表偏倚分析。结果最终纳入6篇文献(含9项研究),包含2 179例IgA肾病患者和1 769例健康对照。Meta分析结果显示,Megsin基因rs1055901、rs1055902多态性位点与亚洲人群IgA肾病易感性无明显关联。然而,Megsin基因rs2689399位点与亚洲人群IgA肾病易感性呈显著负相关(G和C:OR=0.754,95%CI 0.592~0.961,P=0.022;GG和CC:OR=0.506,95%CI0.287~0.892,P=0.019;GG和GC+CC:OR=0.551,95%CI0.316~0.961,P=0.036)。结论 Megsin基因的rs2689399位点的G等位基因、GG基因型可能是亚洲人群IgA肾病的保护因子。Objective To assess the association of three polymorphisms in Megsin（rs1055901,rs1055902 and rs2689399）and susceptibility of IgA nephropathy in Asian population.Methods We conducted a comprehensive search of electronic CNKI,VIP,WangFang Data,CBM,Pubmed,Web of Science and Google Scholar database on the association between Megsin rs1055901,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population（last search update on 2 May2016）.Stata 12.0software was used to calculate the odds ratio（OR）and 95%CI（confidence interval）,as well as sensitivity and publication bias analyses.Results Six publications encompassing nine case-control studies were finally included,including 2 179 cases and 1 769 controls.Finally,no significant association between Megsin rs1055901 and rs1055902polymorphism and IgA nephrology in Asian population was identified,while a significantly decreased risk of IgA nephrology for rs2689399 polymorphism,was identified in Asian population（G and C：OR=0.754,95%CI 0.592-0.961,P=0.022;GG and CC：OR=0.506,95%CI 0.287-0.892,P=0.019;GG and GC＋CC：OR=0.551,95%CI0.316-0.961,P=0.036）.Conclusion Rs2689399 Gallele and GG genotype of Megsin may be the protective factors for IgA nephropathy in Asian population.

关 键 词：肾小球肾炎 IGA 疾病易感性 连锁不平衡 MEGSIN 多态性 META分析 

分 类 号：R692.3[医药卫生—泌尿科学]