1476株鲍曼不动杆菌的临床分布及耐药性特点  

Distribution and clinical drug-resistant character of 1 476 Acinetobacter baumannii isolates

作　　者：刘延媛[1] 张瑞凌[2] 曹海燕[3] 刘汉冕[1] 叶初阳[1] 张扣兴[2] 

机构地区：[1]中山大学附属惠州中心人民医院综合ICU,广东惠州516001 [2]中山大学附属第三医院综合ICU,广东广州510630 [3]中山大学附属惠州中心人民医院细菌室,广东惠州516001

出　　处：《热带医学杂志》2017年第1期103-105,共3页Journal of Tropical Medicine

基　　金：惠州市科技局基金(20150801)

摘　　要：目的了解鲍曼不动杆菌的临床分布及耐药性特点。方法 1 476株鲍曼不动杆菌经Vitek2 Compact鉴定,使用AST-GN16药敏卡进行MIC药敏试验,结合医院病案系统,对菌株及耐药菌株检出患者的临床特征进行分析。结果 98.10%菌株来自住院病人,男性病人占69.11%。儿科、烧伤科、神经外科、ICU、呼吸科、神经内科等科室是检出鲍曼不动杆菌较多的科室。ICU是检出耐药菌株数比例最高科室,其对泰能耐药率上升最快;儿科耐药菌检出数很少,耐药率持续在低水平。年龄≤50岁检出的多重耐药鲍曼不动杆菌主要分布在烧伤科、神经外科和ICU,年龄>50岁检出的多重耐药鲍曼不动杆菌主要分布在呼吸科和ICU,不同年龄组检出多重耐药鲍曼不动杆菌的病区分布差异有统计学意义(Z=5.652,P<0.05)。结论年龄和疾病对医院内病人感染鲍曼不动杆菌有影响,环境中耐药鲍曼不动杆菌的污染导致耐药率增加的情况不容忽视。Objective To investigate the distribution and drug resistant of Acinetobacter baumannii（A. baumannii） isolates.Methods 1 476 isolates were identified by Vitek2 Compact system and were performed antimicrobial susceptibility test by AST-GN16 plate. The difference of age and wards distribution of patients who were infected by A. baumannii,the epidemiology and resistant trend in clinical isolates of A. baumannii were analyzed. Results 98.10% AB isolates were came from hospitalized patients and 69.11% were male. The detection of A. baumannii in Department of Pediatrics,Burns,Neurosurgery,ICU,Respiratory and Neurology,were than in the other departments. ICU had the highest proportion of detection of drug-resistant strains. The drug resistant rate was low in A. baumannii strains isolated from the Pediatrics Department. Patientsof ≤50 years old detected with multi-drug resistant（MDR）A. baumannii were mainly from Burns department,Neurosurgery Department and ICU,while patients 〉50 years old detected with with MDR A. baumannii were most distributed in Departments of Respiratory medicine and ICU. Such distribution showed a significant difference（P〈0.05）. Conclusion The age and type of disease of the hospitalized patient were correlated with the A. baumannii infection. The contamination of drug-resistant A. baumannii in the environment led to increased drug resistance should not be ignored.

关 键 词：鲍曼不动杆菌 耐药 多重耐药菌株 

分 类 号：R378.99[医药卫生—病原生物学]