刺络拔罐法配合清脂颗粒治疗中重度脂肪性肝病临床研究  

Clinical Study on Blood-Letting Puncturing and Cupping Combined with Qingzhi Granule in the Treatment of Moderate and Severe Fatty Liver

作　　者：王真权[1] 杜明[1] 骆璐璐 祖季铭 

机构地区：[1]秦皇岛市中医医院,河北秦皇岛066000

出　　处：《中医学报》2017年第2期304-308,共5页Acta Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2015318)

摘　　要：目的:探讨刺络拔罐法配合清脂颗粒治疗中重度脂肪性肝病的临床疗效。方法:选择111例中重度脂肪性肝病患者为研究对象,均经过肝脏穿刺和B超检查确诊,并伴有肝功能异常及高脂血症。将所有患者随机分为两组,即治疗组57例和对照组54例,治疗组患者给予刺络拔罐法配合清脂颗粒治疗,对照组患者给予荷丹片、硫普罗宁治疗,均连续治疗30 d。比较两组患者治疗前后B超积分及肝脏病理改变,包括丙氨酸氨基转移酶(alanine aminotransferase,ALT)、门冬氨酸氨基转移酶(aspartate transaminase,AST)、谷氨酰转移酶(glutamine transferase,GGT),并对血脂进行检测,包括三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)。同时比较两组患者中医证候积分、血脂、肝功能变化情况和临床疗效。结果:与治疗前相比,两组患者ALT、AST、GGT、TG、TC、中医证候积分、B超积分均明显下降,差异具有统计学意义(P<0.05);治疗30 d后,治疗组患者ALT、AST、GGT、TG、TC、中医证候积分、B超积分及脂肪性肝硬变、脂肪性肝炎比例均明显低于对照组(P<0.05),而单纯性脂肪性肝病、正常比例均明显高于对照组,差异具有统计学意义(P<0.05);治疗组的临床疗效明显优于对照组,差异具有统计学意义(P<0.05)。结论:对中重度脂肪性肝病患者应用刺络拔罐法配合清脂颗粒治疗,可有效改善患者的血脂水平及肝功能,显著提高治疗效果。Objective To investigate the clinical efficacy of blood-letting puncturing and cupping combined with Qingzhi Granule in the treatment of moderate and severe fatty liver. Methods 111 cases of patients with moderate and severe fatty liver were selected as the research objects, all patients were diagnosed by liver puncture and B ultrasound examination and they accompanied with abnor- mal liver function and hyperlipidemia. All patients were randomly divided into treatment group （ n = 57 ） and control group （ n = 54）. Patients in the treatment group were treated with blood-letting puncturing and cupping combined with Qingzhi Granule, and patients in the control group were given Hedan table and tiopronin, both the two groups received continuous 30d treatment. B ultra- sound and hepatic pathological changes,TCM score,blood lipid and liver function changes,and clinical efficacy before and after treatment in two groups were compared. Results Before treatment, compared B ultrasound score, TCM score, blood lipid and liver function indexes in the treatment group with that of control group, the difference had no statistical significance （ P 〉 0.05 ）. Com- pared with pre-treatment, ALT, AST, GGT, TG, TC, TCM score and B ultrasound score in the two groups all significantly declined, and the difference had statistical significance （ P 〈 0.05 ）. After 30d treatment, ALT, AST, GGT, TG, TC, TCM score, B ultrasound score, the ratio of fatty cirrhosis and steatohepatitis in the treatment group were obviously lower than that of Control group, simple fatty liver and normal proportion were obviously higher than control group, and the difference had statistical significance ~ P 〈 0. 05）. The clinical efficacy of treatment group was significantly better than that of control group, and the difference had statistical significance （P 〈 0.05）. Conclusion Blood-letting puncturing and cupping combined with Qingzhi Granule in the treatment of pa- tients with moderate and severe fatty liver can effectively improve pa

关 键 词：中重度脂肪性肝病 刺络拔罐法 清脂颗粒 针灸疗法 

分 类 号：R245.755[医药卫生—针灸推拿学]