卡宾钯配合物催化合成香豆素类衍生物的研究  

Study on the Synthesis of Coumarin Derivatives by Palladium Carbene Complex

作　　者：李艳芳[1] 黄菲东 兰小兵[1] 欧阳嘉盛 刘丰收[1] 

机构地区：[1]广东药科大学医药化工学院,广东中山528458

出　　处：《广东化工》2017年第4期10-11,共2页Guangdong Chemical Industry

摘　　要：香豆素类衍生物因其多样的生物活性备受关注。本文通过Suzuki-Miyaura偶联反应对其结构进行修饰,以3-溴香豆素与各种取代的苯硼酸为原料,催化合成了9种香豆素类衍生物,丰富了香豆素衍生物的种类,以供进一步的药理与工业研究。Coumarin derivatives have been playing important roles due to their various bioactivity. This paper have synthesized nine kinds of them for further medical and industrial research via the Suzuki-Miyaura coupling reaction with 3-bromo coumarin and different substitutent phenylboronic acids acting as raw materials.

关 键 词：香豆素 衍生物 结构修饰 

分 类 号：TQ456.306[化学工程—农药化工]