苍耳子炮制前后的抗炎、镇痛作用比较  

Anti-inflammatory and analgesic actions of Xanthii Fructus and its processed product

作　　者：李蒙[1] 沈佳瑜 李听弦 王光忠[1,2] 

机构地区：[1]湖北中医药大学药学院 [2]湖北省中药炮制工程技术研究中心,湖北武汉430065

出　　处：《中国医院药学杂志》2017年第3期232-234,共3页Chinese Journal of Hospital Pharmacy

基　　金：湖北省自然科学基金项目(编号:2013CFB065)

摘　　要：目的:比较苍耳子炮制前后抗炎、镇痛作用的差别。方法:采用二甲苯耳肿胀实验、角叉菜胶足肿胀实验评价苍耳子炒制前后抗炎作用;以小鼠扭体法、热板法观察苍耳子炒制前后的镇痛作用。结果:苍耳子生品、炒品灌胃小鼠0.5,1.0g·kg^(-1)剂量,能抑制二甲苯引起的耳肿胀(P<0.05)以及角叉菜胶引起的足肿胀(P<0.05);对化学刺激性、热刺激性疼痛均有明显的镇痛作用(P<0.05),并呈现剂量依赖性。苍耳子炒品与生品比较,抗炎、镇痛作用无明显差异(P>0.05)。结论:苍耳子炒制前后具有较好的抗炎、镇痛作用,为其临床应用提供了实验依据。OBJECTIVE To compare anti-inflammatory and analgesic actions of Xanthii Fructus（XF）and processed Xanthii Fructus（PXF）.METHODS The xylene ear swelling test and the carrageenan paw edema test were used to evaluate the antiinflammatory activities,hot plate test and acetic writhing test were used to study analgesic activities of Xanthii Fructus and its processed product in mice.RESULTS Both in mice at drug doses of 0.5 and 1.0g·kg^-1,Xanthii Fructus and its processed product could significantly inhibit the xylene-induced ear swelling and carrageenan-induced paw swelling,reduce the writhing actions induced by the intraperitoneal injection of acetic acid in mice,increase the hot plate pain threshold in a dose dependent manner（P〈0.05）.Anti inflammatory and analgesic effects were not significantly different between Xanthii Fructus and processed Xanthii Fructus（P〉0.05）.CONCLUSION Xanthii Fructus and processed Xanthii Fructus show good anti-inflammatory and analgesic effects in mice,and the results provide an experimental basis for its clinical application.

关 键 词：生苍耳子 炒苍耳子 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]