补肾活血颗粒对绝经后微血管性心绞痛患者血管内皮功能及炎症因子的影响  

Effect of Reinforcing Kidney and Activating Blood Granules on Vascular Endothelial Function and Inflammatory Factor of Postmenopausal Patients with Microvascular Angina(MVA)

作　　者：罗文平[1] 汶医宁[1] 史凡凡[1] 王永刚[2] 马静[3] 

机构地区：[1]陕西中医药大学附属医院,陕西咸阳712000 [2]陕西中医药大学第二附属医院,陕西咸阳712000 [3]第四军医大学,陕西西安710032

出　　处：《实用中医药杂志》2017年第3期227-228,共2页Journal of Practical Traditional Chinese Medicine

基　　金：陕西省教育厅科学研究计划项目(2014JK1190)

摘　　要：目的:研究补肾活血颗粒对绝经后微血管性心绞痛患者血管内皮功能及炎症因子的影响。方法:124例随机分为两组,对照组39例给予常规西药治疗,治疗组85例在与对照组治疗相同的基础上加服补肾活血颗粒,治疗3个月后观察相关血清学指标。结果:治疗组NO含量水平明显高于对照组,ET-1、IL-1、CRP含量水平明显低于对照组(P<0.05)。两组TNF-α、IL-6含量水平差异无统计学意义(P>0.05)。结论:补肾活血颗粒可能通过调节微血管性心绞痛患者炎症因子的表达以及对血管内皮功能的修复从而达到治疗作用。Objective： To study the effect of Reinforcing Kidney and Activating Blood Granules on vascular endothelial function and inflammatory factor of postmenopausal patients with microvascular angina（MVA）. Method： 124 cases were divided into 2 groups in random. 39 cases were given traditional anti angina pectoris treatment as the control group while 85 cases were treated with Reinforcing Kidney and Activating Blood Granules additionally based on the treatment of the control group as the study group. The relative serum markers were observed after 3 m continuous treatment. Result： The content level of NO of the treatment group was higher than that of the control group significantly while the content level of ET-1, IL-1 and CRP of the treatment group was lower than that of the control group significantly （P〈0.05） . There was no statistical significance in the content level of TNF-α and IL-6 between the two groups （P〉0.05） . Conclusion： Reinforcing Kidney and Activating Blood Granules performs the therapeutic effect, maybe by regulating the expression of inflammatory factor and repairing the endothelial function.

关 键 词：补肾活血颗粒 绝经 微血管性心绞痛 血清学指标 

分 类 号：R256.224.14[医药卫生—中医内科学]