苦瓜中有效成分抗肿瘤研究进展  

Progress of active components on anti-tumor in Momordica charantia

作　　者：谢羽[1] 伍春莲[1] 

机构地区：[1]西华师范大学西南野生动植物资源保护省部共建教育部重点实验室,南充637009

出　　处：《药物分析杂志》2017年第2期185-190,共6页Chinese Journal of Pharmaceutical Analysis

基　　金：四川省教育厅重大培育项目(13CZ0029);中国博士后基金第54批面上一等资助(2013M540391);三峡库区生态环境与生物资源省部共建重点实验室开放课题基金项目(SKL-2011-05)

摘　　要：苦瓜中含有各种丰富的有效成分,这些有效成分在抗癌机制中主要具有降糖、减脂、抗突变、抗氧化、抗癌细胞增值、转移以及诱导癌细胞凋亡的作用。本文综述了苦瓜中含有的维生素C、β-胡萝卜素、番茄红素、α-苦瓜素、β-苦瓜素、多酚类物质和苦瓜皂苷、甘油二酯、维生素B_(17)、奎宁蛋白有效成分在抗癌中的研究进展,展望了其免疫原性强,血浆半衰期短,降低毒性等特点作为应用于临床的前提,并对苦瓜中对病人不好的抗生育蛋白(α-苦瓜籽蛋白和核糖体失活蛋白)用来作为抗虫药意义重大。Momordica charantia contains a variety of active ingredients,and the active components in anti-cancer mechanism mainly includes antibacterial,reduction of blood sugar,reduced fat,resistance mutations,anti-oxidation,cancer cell proliferation,metastasis and the role of inducing cancer cell apoptosis.Various active ingredients in Momordica charantia and the related research progress were reviewed,such as vitamin C,beta-carotene and lycopene,alpha-momorcharin,beta-momorcharin,polyphenolic substance and balsamper glycoside,diacylglycerol,vitamin B_（17）,quinine protein,MAP30 protein,fatty acids.Prospect of strong immunogenicity,short plasma half-life,and redced toxicity are expected as a prerequisite for clinical application.In addition,the alpha-Momordica charantia seed proteins and ribosome-inactivating proteins,which are not good for patients,are of great significance used as antifungal agents.

关 键 词：苦瓜 抗肿瘤 抗癌机制 研究进展 

分 类 号：R917[医药卫生—药物分析学]