犬用盐酸特比萘芬喷雾剂处方筛选及含量测定研究  

Prescription-screening and Determined the Content of Hydrochloride Terbinafine Sprays for Dogs

作　　者：马军明[1] 杨柳[1] 杜守颖[1] 谭宁[1] 赵梦迪[1] 王承[1] 白洁[1] 陆洋[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国兽药杂志》2017年第2期49-53,共5页Chinese Journal of Veterinary Drug

基　　金：北京市科技新星计划资助(xx2015A048);2015年青年骨干教师专项(2015-JYB-QNJSZX004)

摘　　要：对犬用盐酸特比萘芬喷雾剂进行处方筛选并对盐酸特比萘芬进行含量测定。以喷雾剂成型性为指标优选出2%月桂氮卓酮(水溶性),0.35 g/L苯甲酸钠,10%KolliphorHS 15和适量高纯水制成水溶液。采用HPLC法测定该处方中有效成分盐酸特比萘芬的含量,结果显示盐酸特比萘芬在0.0201~0.4026 mg/m L的浓度范围内线性关系良好,回归方程为Y=2.652×107X-2.418×104(r=0.9998,n=6),平均回收率为104.14%,RSD为1.23%。通过采用HPLC法测量有效成分盐酸特比萘芬的含量稳定,所筛选的处方工艺可行,制备方法简单方便。The present experiment focused on the dogs with hydrochloride terbinafine sprays which the prescription was screening and the content of hydrochloride terbinafine was going to be determined. Forming the spray which was based on the index of its formability, the prescription were made up of laurocapram （ water - soluble）, sodium benzoate, 10% Kolliphor~ HS 15 and purity water that formulated the aqueous solution. Then the active ingredient content of terbinafine hydrochloride was determined by HPLC. The content determination of hydrochloride terbinafine concentration in the range of 0. 0201 × 0. 4026 mg/mL had a good linear relationship, the regression equation was Y = 2. 652 ×10^7X - 2. 418× 10^4 （ r = 0. 9998, n = 6） , the average rate of recovery was 104.14%, RSD was 1.23%. The active ingredient content of hydroehloride terbinafine was stable by HPLC. The screened prescription was feasible, and the formulation process of preparation was simple.

关 键 词：盐酸特比萘芬 喷雾剂 处方筛选 含量测定 

分 类 号：S859.79[农业科学—临床兽医学]