管状胃制作宽度对犬胃组织微循环灌注及反流功能的影响  

Effect of Stomach Tube Width on Microcirculation Perfusion and Reflux Function of Gastric Tissues in Dogs

作　　者：王明[1] 夏彦民 王文辰[1] 姜涛[1] 

机构地区：[1]第四军医大学附属唐都医院胸外科,西安710038

出　　处：《解放军医药杂志》2017年第2期48-51,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：陕西省卫生科研项目(2014A3)

摘　　要：目的探索管状胃胃体宽度对胃组织微循环灌注及反流功能、术后吻合口瘘的影响。方法 90只雄性比格犬随机分为A、B、C组,每组30只,分别制作管状胃胃体宽度为2/3、1/2、1/3原胃模型。比较3组手术时间、术中出血量及术后吻合口瘘发生率;采用超声造影技术比较3组胃组织微循环灌注情况;采用p H监测仪监测管状胃内p H值、反流次数及时间。结果 C组手术时间显著长于A、B组(P<0.05),B组显著长于A组(P<0.05);C组术中出血量显著多于A、B组(P<0.05);B组术后吻合口瘘发生率显著低于A、C组(P<0.05)。B组曲线下面积显著高于A、C组(P<0.05),A组显著高于C组(P<0.05);B组曲线上升支斜率显著高于A、C组(P<0.05);B组曲线达峰时间均少于A、C组(P<0.05)。A组胃内p H<4总时间显著长于B、C组(P<0.05),B组显著长于C组(P<0.05);A组反流次数显著多于B、C组(P<0.05),B组显著多于C组(P<0.05);A组最长反流时间显著长于B、C组(P<0.05),B组显著长于C组(P<0.05)。结论管状胃宽度对术后吻合口瘘发生率、微循环灌注及反流情况影响巨大,过宽及过窄均不好,管状胃宽度为原胃1/2具有较高的应用价值。Objective To investigate effect of stomach tube width on microcirculation perfusion,reflux function and postoperative anastomotic fistula of gastric tissues in dogs. Methods A total of 90 male beagle dogs were randomly divided into group A,B and C（ n = 30 for each group）,and then stomach tube models of 2 /3,1 /2 and 1 /3 original stomach width were made respectively. In three groups,operative time,intraoperative bleeding volume and incidence rate of postoperative anastomotic fistula were compared; microcirculation perfusion conditions of gastric tissues were compared by ultrasonography; PH detector was used to detect PH value,times of gastroesophageal reflux and reflux duration. Results Operative time in group C was significantly longer than those in group A and B（ P〈0. 05）,and the time in group B was significantly longer than that in group A（ P〈0. 05）. Intraoperative bleeding volume in group C was significantly more than those in group A and B（ P〈0. 05）. Incidence rate of postoperative anastomotic fistula in group B was significantly lower than those in group A and C（ P〈0. 05）. Area under curve in group B was significantly larger than those in group A and C（ P〈0. 05）,and the area in group A was significantly larger than that in group C（ P〈0. 05）. Curve upstroke slope in group B was significantly higher than those in group A and C（ P〈0. 05）. Time to peak in group B was significantly shorter than those in group A and C（ P〈0. 05）. The total time of PH 4 in stomach in group A was significantly longer than those in group B and C（ P〈0. 05）,and the time in group B was significantly longer than that in group C（ P〈0. 05）. Times of reflux in group A was significantly more than those in group B and C（ P〈0. 05）,and the time in group B was significantly more than that in group C（ P〈0. 05）. The longest reflux time in group A was significantly longer than those in group B and C（ P〈0. 05）,and the time in group B was significantly longer than that

关 键 词：管状胃 胃体宽度 微循环灌注 反流功能 犬 

分 类 号：R656.61[医药卫生—外科学] R331.323[医药卫生—临床医学]