线粒体融合-分裂在脓毒症发病机制中的作用  

Mitochondrial fusion and fission in the pathogenesis of sepsis

作　　者：孙中媛 张琪[1] 

机构地区：[1]北京大学首都儿科研究所教学医院重症医学科,100020

出　　处：《国际儿科学杂志》2017年第2期85-89,共5页International Journal of Pediatrics

摘　　要：脓毒症是感染导致的全身炎症反应综合征，进一步发展可导致感染性休克和多器官功能障碍综合征。脓毒症具有高发病率及病死率，是危重症领域的研究热点。近年来，亚细胞相关研究提示线粒体损害在脓毒症患者（尤其是脓毒症休克患者）的病情发展中起着非常重要的作用。线粒体是细胞内高度动态变化的细胞器，在细胞内不断融合与分裂，形成动态平衡的网状结构。脓毒症时，线粒体融合与分裂失衡，导致细胞内分子、细胞以及器官均发生功能障碍。该文就线粒体融合．分裂改变在脓毒症发病机制中作用的研究进展作一综述。Sepsis is a systemic inflammatory response syndrome caused by infection, and further development can lead to septic shock and multiple organ dysfunction syndrome. Clinical research of sepsis morbidity and mortality is a hot topic in this field. Subcellular related studies in recent years show that mitochondrial damage plays a very important role in the development of sepsis, especially septic shock. Mitochondria are highly dynamic organelles in the cell. They continue to merge and divide within cells, forming a dynamic equilibrium network structure. In sepsis, imbalance of mitochondrial fusion and fission leads to disorders of the intracellular mol- ecules, cells, and organs. This article reviews the progress in the investigation of mitochondrial fusion and fission in the pathogenesis of sepsis.

关 键 词：脓毒症 线粒体融合-分裂 

分 类 号：R459.7[医药卫生—急诊医学]