杞菊地黄丸联合西药治疗干眼症疗效与安全性Meta分析  

Clinical Efficacy of Qiju Dihuang Pill Combined with Western Medicine on Curing Xerophthalmia:A Meta-Analysis

作　　者：刘枚芳 练鹏颖 李佩珊[1] 江颖[1] 张伟键[1] 刘焱杰 陈兹满[2] 

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医院,广东广州510120

出　　处：《辽宁中医药大学学报》2017年第2期108-111,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(61301294);国家级大学生创新创业训练计划项目(201510572006);张梅芳全国名老中医专家传承工作室项目(201420)

摘　　要：目的:综合评价杞菊地黄丸联合西药治疗干眼症的疗效和安全性。方法:计算机检索Pub Med、CBM、CNKI、VIP和Wan Fang Data等数据库,查找相关随机对照试验,检索时限均从建库至2016年2月。按纳入与排除标准筛选文献、提取数据和评价纳入研究的方法质量后,采用Revman5.3软件对有效数据进行Meta分析。结果:共纳入10篇随机对照临床试验(randomized controlled trials,RCTs)文献,病例共856例。Meta分析结果显示,杞菊地黄丸联合西药治疗干眼症在总有效率[OR=5.20,95%CI(3.16,8.58)]、泪液分泌量(schirmer)[MD=1.96,95%CI(0.64,3.28)]、泪膜破裂时间(BUT)[MD=3.10,95%CI(2.26,3.95)]、不良反应[OR=0.72,95%CI(0.33,1.55)]等方面均优于对照组(P<0.00001),其差异均有统计学意义。结论:杞菊地黄丸联合西药治疗干眼症患者的总体疗效优于单纯西药组,治疗后的schirmer、BUT也优于单纯西药组;杞菊地黄丸联合西药有助于提高干眼症患者的总体疗效和安全性,但由于所纳入的文献质量不高,仍需要大样本、多中心、双盲RCT的支持。Objective： To systematically review the effectiveness and safety of Qiju Dihuang Pill combined with Western medicine to treat xerophthalmia. Methods ： Such databases as Pubmed, Embase, Cochrane library, CNKI, CBM, WanFang Data and VIP database are searched to collect randomized clinical trials on the effectiveness and safety of Qiju Dihuang Pill for xerophthalmia till September, 2015. According to the inclusion and exclusion criteria, literature was screened, data were extracted, and the methodological quality of included studies was also assessed. Then, meta-analysis was performed using RevMan 5.3 soft ware. Results ： 10 RCTs were included eventually among a total of 856 cases on Qiju Dihuang Pill combined with Western medicine in the treatment of xerophthalmia. The analysis shows that Qiju Dihuang Pill combined with Western medicine in the treatment of xerophthalmia are superior to the control group in total efficiency[OR=5.20,95%CI （ 3.16,8.58 ）], schirmer [MD=1.96,95%CI = （ 0.64,3.28 ）] and tear film breakup time （ BUT ） [MD=3.10,95%CI= （ 2.26,4.28 ） and adverse reactions[OR=0.72,95%CI （ 0.33,1.55 ） ] （ P〈0.00001 ）. Conclusion ： Qiju Dihuang Pill combined with Western medicine in the treatment of xerophthalmia has a certain effect and better clinical effectiveness than the control group in total efficiency, schirmer and tear film breakup time （ BUT ）. However, more randomized and double-blind experiments of high quality with rigorous design and multicenter need to be verified because of the poor quality of the existing researches.

关 键 词：杞菊地黄丸 干眼症 随机对照试验 META分析 

分 类 号：R591.412[医药卫生—内科学]