血清CRP与老年原发性高血压患者颈动脉粥样斑块的相关性分析  

Correlation Analysis Between Serum C Reactive Protein and Carotid Artery Plaque in Elderly Patients with Primary Hypertension

作　　者：廖富彪 周颖玲[2] 陈竹君[2] 

机构地区：[1]云浮市人民医院心内科,广东云浮527300 [2]广东省心血管病研究所心内科,广东广州510100

出　　处：《锦州医科大学学报》2017年第1期26-29,共4页Journal of Jinzhou Medical University

摘　　要：目的探讨血清反应蛋白(CRP)与老年原发性高血压患者颈动脉粥样斑块的相关性。方法选择2014年1月至2015年12月我院收治的98例老年原发性高血压患者为研究对象,运用颈动脉超声检测患者颈动脉内中膜厚度(IMT),观察患者颈动脉斑块情况,采用免疫学方法定量检测患者血清CRP,并进行血清CRP与颈动脉内中膜增厚、斑块之间的相关性分析。结果 IMT≥1.3 mm、IMT 1.0~1.3 mm患者的脉压(PP)、收缩压(SBP)、血清CRP水平高于IMT≤1 mm患者,舒张压(DBP)低于IMT≤1 mm患者,并且IMT≥1.3 mm患者的PP、SBP、血清CRP水平高于IMT 1.0~1.3 mm患者,DBP低于IMT 1.0~1.3 mm患者,差异均有统计学意义(P<0.05);Spearman秩相关分析显示IMT分级与CRP呈正相关关系(r=0.451,P=0.032)。高血压3级和2级患者的IMT、血清CRP水平高于高血压1级,并且高血压3级患者的IMT、血清CRP水平高于高血压2级,差异均有统计学意义(P<0.05);Spearman秩相关分析显示高血压分级与CRP呈正相关关系(r=0.321,P=0.039)。颈动脉粥样斑块分级1级、2级、3级患者的CRP水平高于0级,2级、3级高于1级,且3级高于2级,差异均有统计学意义(P<0.05);Spearman秩相关分析显示不同颈动脉粥样斑块分级与CRP呈正相关关系(r=0.423,P=0.034)。结论血清CRP水平与老年原发性高血压患者颈动脉IMT、斑块级别呈现一定的正相关性关系,血清CRP对高血压颈动脉粥样硬化的发现与治疗有临床指导意义。Objective To investigate the correlation between the serum C reactive protein （CRP） and carotid artery plaque in elderly patients with primary hypertension. Methods 98 cases of elderly patients with primary hypertension treated in our hospital from January 2014 to December 2015 were selected as study subjects. Intima media thickness （IMT） of carotid artery was detected by carotid ultrasound and carotid artery plaque was observed. The levels of serum CRP were detected by immunological method, and the correlations among serum CRP, IMT of carotid artery and carotid artery plaque were analyzed. Results The levels of PP, SBP, serum CRP of patients with IMT ≥1.3 mm and patients with IMT 1.0 - 1.3 mm were higher than those of patients with IMT ≤ 1 mm, and DBP level was lower than that of patients with IMT ≤1 mm. The levels of PP, SBP, serum CRP of patients with IMT≥1. 3 mm were higher than those of patients with IMT 1.0 - 1.3 ram, and DBP level was lower than that of patients with IMT 1.0 - 1.3 ram. The differences were statistically significant （ P〈0. 05 ）. Spearman rank correlation analysis showed the positive correlation between IMT grading and serum CRP （r--＇-0. 451, P=0. 032）. The levels of IMT, CRP of patients with hypertension grade 3 and grade 2 were higher than those of patients with hypertension grade 1, and the levels of IMT, CRP of hypertension grade 3 patients were higher than those of hypertension grade 2 patients. The differences were statistically significant （ P〈0.05 ）. Spearman rank correlation analysis showed a positive correlation between hypertension grading and CRP （r = 0. 321, P = 0. 039）. The serum CRP level of carotid artery plaque grade 1, grade 2, grade 3 was higher than that of grade 0, to be specific, grade 2, grade 3higher than grade 1, and grade 3 higher than grade 2. The differences were statistically significant （ P〈0. 05 ）. Spearman rank correlation analysis showed a positive correlation between different carotid artery plaque grades and CRP �

关 键 词：原发性高血压 颈动脉粥样斑块 C反应蛋白 相关性 

分 类 号：R543.5[医药卫生—心血管疾病]