血清心肌肌钙蛋白T、CRP水平与维持性血液透析患者预后的相关性研究  

Study on the correlation between the levels of serum cardiac troponin T,C-reactive protein and the prognosis in patients with maintenance hemodialysis

作　　者：孟梅霞[1] 张莉[1] 王昌[1] 张媛[1] 

机构地区：[1]陕西省西安市第四医院肾内科,陕西西安710004

出　　处：《实用临床医药杂志》2017年第1期45-47,51,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨影响维持性血液透析(MHD)患者预后的相关因素。方法 105例MHD患者,随访2年,统计患者临床资料,记录随访结果,分析C-反应蛋白(CRP)和血清心肌肌钙蛋白T(c Tn T)与MHD患者预后的关系。结果 105例MHD患者平均随访(20.68±1.32)个月,其中血清c Tn T阳性27例(25.71%),血清CRP阳性31例(29.52%),两者均阳性15例(14.29%),随访期间死亡21例(20.00%)。c Tn T阳性患者的死亡率显著高于其阴性患者(P<0.01),CRP阳性患者的死亡率显著高于其阴性患者(P<0.01),两者均为阳性患者的死亡率显著高于均为阴性和阴阳合并的患者(P<0.05或P<0.01)。生存分析显示,c Tn T阳性、CRP阳性及两者均为阳性对MHD患者的生存有显著影响。结论血清c Tn T和CRP水平与MHD患者预后具有显著的相关性。Objective To explore the relevant influencing factors of the prognosis of patients with maintenance hemodialysis（ MHD）. Methods Totally 105 patients with MHD were followed up for two years. Their clinical data were collected,and follow-up results were recorded. The relationships between C-reactive protein（ CRP）,serum cardiac troponin T（ c Tn T） and the prognosis of patients with MHD were analyzed. Results A total of 105 patients with MHD were followed up for（ 20. 68 ± 1. 32） months,in which there were 27 cases（ 25. 71%） with positive c Tn T,31 cases（ 29. 52%） with positive CRP,and 15 cases（ 14. 29%） with positive c Tn T and CRP. Twenty-one cases（ 20. 00%） were dead in follow-up period. The mortality of patients with sample positive c Tn T or CRP was significantly higher than those with sample negative c Tn T or CRP（ P〈0. 01）,and the mortality of patients with both positive c Tn T and CRP was markedly higher than those with both negative ones and those with one positive and one negative（ P〈0. 05 or P〈0. 01）. Survival analysis revealed that the survival of patients with MHD was significantly correlated with the influence of positive c Tn T,positive CRP and positive c Tn T and CRP. Conclusion The levels of serum c Tn T and CRP are significantly correlated with the prognosis of patients with MHD.

关 键 词：心肌肌钙蛋白T C反应蛋白 维持性血液透析 死亡 生存 

分 类 号：R459.5[医药卫生—治疗学]