The emerging roles of the DDX41 protein in immunity and diseases  

作　　者：Yan Jiang Yanping Zhu Zhi-Jie Liu Songying Ouyang 

机构地区：[1]National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2]iHuman Institute, Shanghai Tech University, Shanghai 201210, China [3]Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA

出　　处：《Protein & Cell》2017年第2期83-89,共7页蛋白质与细胞（英文版）

基　　金：ACKNOWLEDGMENTS This work was supported by the National Basic Research Program （973 Program） （No. 2014CB910400 and 2013CB911103）, the National Natural Science Foundation of China （Grants No. 31570875, 31330019, 81590761, 31560727 and 81501353）, the Beijing Nova Program （Grant No. Z141102001814020） to S.O., Youth Innovation Promotion Association CAS （Grant No. 2013065） to S.O., and the special project of Ebola virus research from the president foundation of Chinese Academy of Sciences.

摘　　要：RNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay. DExD/H-box hell- cases compdse the largest SF2 helicase superfamily, which are characterized by two conserved RecA-like domains. In recent years, an increasing number of unexpected functions of these proteins have been discovered. They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recant literatures on one member of the SF2 superfamily, the DEAD- box protein DDX41. After bacterial or viral infection, DNA or cyclic-di-GMP is released to cells. After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons （IFN）. After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. Besides the roles in Innate immunity, DDX41 is also related to diseases. An increasing number of both inherited and acquired mutetions in DDX41 gane are identified from myelodysplastic syndrome and/or acute myeloid leukemia （MDS/AML） patients. The review focuses on DDX41, as well as its homolog Abstrakt in Drosophila, which is important for survlval at all stages throughout the life cycle of the fly.RNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay. DExD/H-box hell- cases compdse the largest SF2 helicase superfamily, which are characterized by two conserved RecA-like domains. In recent years, an increasing number of unexpected functions of these proteins have been discovered. They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recant literatures on one member of the SF2 superfamily, the DEAD- box protein DDX41. After bacterial or viral infection, DNA or cyclic-di-GMP is released to cells. After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons （IFN）. After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. Besides the roles in Innate immunity, DDX41 is also related to diseases. An increasing number of both inherited and acquired mutetions in DDX41 gane are identified from myelodysplastic syndrome and/or acute myeloid leukemia （MDS/AML） patients. The review focuses on DDX41, as well as its homolog Abstrakt in Drosophila, which is important for survlval at all stages throughout the life cycle of the fly.

关 键 词：DDX41 innate immunity RNA helicases myelodysplastic syndrome acute myeloid leukemia 

分 类 号：Q959.115.4[生物学—动物学] S852.4[农业科学—基础兽医学]