Porcine diazepam-binding inhibitor and bovine diazepam-binding inhibitor affect morphine antinociception via different receptors  

作　　者：Yu-Zhen Chen Xiao-Cun Li Zhen-Quan Guo Li Zhou Zhuan Zhou Song-Ping Liang Cai-Hong Wu 

机构地区：[1]State Key Laboratory of Membrane Biology, Peking University, Beijing 100871, China [2]College of Life Sciences, Peking University, Beijing 100871, China [3]PKU-IDG/McGovem Institute for Brain Research and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China [4]Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China [5]College of Life Sciences, Hunan Normal University, Changsha 410006, Hunan, China

出　　处：《Protein & Cell》2017年第2期140-143,共4页蛋白质与细胞（英文版）

基　　金：ACKNOWLEDGEMENTS We thank Dr. lain C Bruce for helpful comments on the manuscript. 77 and ZL were partially supported by grants from the National Basic Research Program （973 Program） （No. 2012CB518006）, and the National Natural Science Foundation of China （Grant Nos. 31228010, 31171026, 31100597, 31327901, 31221002, 31330024, 31400708, 31670843, 31521062, and SQ2011SF11B01041）. Yu-Zhen Chen, Xiao-Cun Li, Zhen-Quan Guo, Li Zhou, Zhuan Zhou, Song-vve no conflict of interest. This article does not contain any studies with human subjects performed by the any of the authors. All institutional and national guidelines for the care and use of laboratory animals were followed.

摘　　要：Opioid addiction is one of the top challenges for society, particularly in China. To fight it, the key is to reveal its underlying mechanisms. Among the strategies to overcome the mental damage caused by opioids, investigating native anti-opioid peptides derived from mammalian （including human） brains is an important option because of safety concerns. In 1983, diazepam-binding inhibitor （DBI）, a 10-kDa peptide, was first derived from rat brains （Guidotti et al., 1983）. After repeated treatment with morphine, the DBI level is enhanced in rodent brains （Katsura et al., 1998; Shibasaki et al., 2006）.Opioid addiction is one of the top challenges for society, particularly in China. To fight it, the key is to reveal its underlying mechanisms. Among the strategies to overcome the mental damage caused by opioids, investigating native anti-opioid peptides derived from mammalian （including human） brains is an important option because of safety concerns. In 1983, diazepam-binding inhibitor （DBI）, a 10-kDa peptide, was first derived from rat brains （Guidotti et al., 1983）. After repeated treatment with morphine, the DBI level is enhanced in rodent brains （Katsura et al., 1998; Shibasaki et al., 2006）.

分 类 号：Q426[生物学—神经生物学] TD923.14[生物学—生理学]