小剂量红霉素对先天性肠旋转不良术后患儿胃肠道功能恢复的影响  

Effect of low-dose erythromycin on recovery of gastrointestinal function of neonates after congenital intestinal malrotation surgery

作　　者：李玉峰[1] 吕昌恒[1] 唐海洲[1] 

机构地区：[1]右江民族医学院附属医院小儿外科,广西百色533000

出　　处：《中国妇幼保健》2017年第4期754-756,共3页Maternal and Child Health Care of China

摘　　要：目的探讨小剂量红霉素在先天性肠旋转不良(CMI)患儿手术后胃肠道恢复中的临床意义。方法分析2010年12月-2015年12月在右江民族医学院附属医院接受Ladd手术治疗的116例CMI新生儿的临床资料,根据术后用药方案将患儿分为A组(常规治疗+小剂量红霉素)60例和B组(常规治疗)56例两组。比较两组患儿的一般资料、临床疗效、胃肠功能恢复情况、全肠内营养达标及开始经口喂养的时间、总住院时间、并发症发生情况。结果两组患儿的一般资料差异无统计学意义(P>0.05)。A组患儿治疗后临床疗效明显优于B组,治疗后肛门开始排气、排便及肠鸣音恢复时间均短于B组。全肠内营养达标及开始经口喂养的时间、总住院时间均显著少于B组,差异均有统计学意义(P<0.01)。治疗后两组患儿均未出现任何并发症。结论采用小剂量红霉素治疗术后CMI患儿的临床疗效显著,不但可以促进患儿胃肠道功能的恢复,而且安全性较高、住院时间短,值得推广。Objective To explore the clinical significance of low-dose erythromycin in recovery of gastrointestinal function of children after congenital intestinal malrotation surgery. Methods The clinical data of 116 neonates with congenital intestinal malrotation who were treated by Ladd surgery in the hospital from December 2010 to December 2015 was analyzed. According to postoperative therapeutic regimens,the neonates were divided into group A（ including 60 neonates treated by conventional treatment and low- dose erythromycin） and group B（ including 56 neonates treated by conventional treatment）. The general information,clinical effects,gastrointestinal function recovery,the time of achieving standard of total enteral nutrition,the time of starting oral feeding,the total hospitalization time,the incidence rates of complications in the two groups were compared. Results There was no statistically significant difference in the general information between the two groups（ P〉0. 05）. The clinical effect after treatment in group A was better than that in group B. The time of anal exhausting and defecating,the time of bowel sounds recovery in group A were shorter than those in group B. The time of achieving standard of total enteral nutrition,the time of starting oral feeding,and the total hospitalization time in group A were statistically significantly shorter than those in group B（ P〈0. 01）. After treatment,no complications occurred in the two groups. Conclusion The clinical efficacy of low-dose erythromycin in gastrointestinal recovery of children with congenital intestinal malrotation is significant,which can promote gastrointestinal recovery with high safety and short hospitalization time,the method is worthy of promotion.

关 键 词：先天性肠旋转不良 小剂量红霉素 胃肠道恢复 盲肠松解术 

分 类 号：R725.7[医药卫生—儿科]