骨转换耦联机制新进展-骨髓局部因子的作用  

The recent progress of bone coupling mechanism： function of bone marrow derived factors

作　　者：许丰[1] 袁凌青[1] 

机构地区：[1]中南大学湘雅二医院代谢内分泌科,长沙410011

出　　处：《中华内分泌代谢杂志》2017年第2期156-158,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（81270962）志谢中南大学中央高校基本科研业务费专项资金资助项目（2016zzts539）

摘　　要：骨重建是一种有序的骨吸收一骨形成耦联过程。不同骨骼细胞所分泌的细胞因子及细胞表面膜分子参与调控骨耦联。深入认识骨耦联机制对于研究和诊断骨质疏松等代谢性骨病有重要的指导意义。本文就一些重要的细胞因子及相关膜分子调控骨耦联机制的新进展加以概述。Bone remodeling is an ordered process of coupling of bone resorption and bone formation. Cytokines secreted by different bone cells and membrane molecules expressed by bone cells are involved in regulation of coupling of bone resorption and bone formation. To reveal the mechanism of bone coupling is of great significance in the study and diagnosis of osteoporosis and other metabolic bone diseases. In the present review, we summarize the progression of mechanisms by which cytokines and the related membrane molecules are regulating the coupling of bone resorption and bone formation.

关 键 词：骨重建 骨耦联 细胞因子 膜分子 

分 类 号：R580[医药卫生—内分泌]