帕金森病认知障碍患者脑结构的体素形态学研究  

Voxel-based morphometry on brain structures in Parkinson’s disease patients with mild cognitive impairment

作　　者：夏建国[1] 田为中[1] 陈锦华[1] 张继[1] 王宁[1] 刘颖[2] 王璐[2] 

机构地区：[1]泰州市人民医院影像科,江苏泰州225300 [2]泰州市人民医院神经内科,江苏泰州225300

出　　处：《实用放射学杂志》2017年第2期173-177,共5页Journal of Practical Radiology

基　　金：泰州市科技支撑计划（社会发展）资助项目（TS201527,SSF20150124）;江苏省“六大人才高峰”资助项目（2015-WSN-119）.

摘　　要：目的：分析帕金森病（PD）患者脑灰质异常区域及分布特征,探寻与轻度认知障碍（MCI）有关的脑结构变化。方法采用基于体素的形态学测量（VBM）方法,对20例伴 PD-MCI 患者、17例无轻度认知障碍 PD（PD-nMCI）患者及20例正常对照组（NC）的3组3D-T1 WI 脑容积数据进行处理统计,得到3组全脑灰质图像。结果与 NC 组相比,PD-nMCI 组脑灰质体积异常减少的脑区包括：右侧梭状回、右颞中下回、右钩回及左侧颞上回。与 PD-nMCI 组相比,PD-MCI 组脑灰质体积异常减少的脑区包括：两侧额叶（两额中下回、左侧中央前回）、颞叶（右颞中回、左颞上回）、岛叶、右枕叶（右楔叶、舌回）、右后扣带回。结论PD-nMCI 患者灰质体积的缺失相对局限,随认知障碍的出现、发展,缺失脑区的范围逐渐扩大,其中两侧额叶中下回、左侧中央前回的体积缺失与 PD 患者的 MCI 关系密切。Objective To investigate the abnormal region of gray matter and distribution in patients with Parkinson’s disease （PD）,and explore the brain structural changes closely related to mild cognitive impairment（MCI）.Methods 20 cases of PD-MCI, 1 7 cases of PD-nMCI and 20 normal controls （NC）were examined by 3D-T1 WI brain volume sequence.The data of three groups were analyzed using voxel-based morphometry（VBM）based on SPM8 to generate gray matter map.Results Compared to NC,decreased gray matter volume in PD-nMCI was observed in the right temporal lobe,including the middle temporal gyrus,inferior temporal gyrus,and right fusiform gyrus,uncus and left superior temporal gyrus.Compared to PD-nMCI,decreased gray matter volume in PD-MCI was observed in the bilateral midfrontal gyrus,inferior frontal gyrus,left precentral gyrus,right midtemporal gyrus,superior temporal gyrus,bilateral insular,and right cuneus,lingual gyrus,posterior cingutate.Conclusion Decreased gray volume in PD-nMCI is mainly located in the right temporal lobe and right uncus.With occurrence of MCI,abnormal brain regions are gradually extended.Gray matter atrophy in the bilateral midfrontal gyrus,inferior frontal gyrus,and left precentral gyrus are related to the MCI.

关 键 词：体素的形态学测量 帕金森病 轻度认知障碍 

分 类 号：R814.49[医药卫生—影像医学与核医学] R742[医药卫生—放射医学]